Nickel toxicity modulating networks identified with proteins whose absence renders cells sensitive to NiSO
. The yeast protein interactome consisting of 5,433 proteins, 14,656 protein-protein interactions, and 5,621 protein-DNA interactions was compiled using the program Cytoscape. Proteins corresponding to nickel sensitive gene deletion strains were mapped onto the interactome and then filtered to identify connected groups of proteins (N => 2). Straight lines indicate protein-protein interactions and arrows indicate DNA-protein interaction.