Table 1 Functional categories overrepresented with proteins whose absence renders cells more sensitive to NiSO4.
MIPS Functional Category | p-value | In Category from Cluster | # Nickel Toxicity Modulating | Total in Category |
|---|---|---|---|---|
homeostasis of proteins [34.01.01.03] | 0.000556 | VMA2 CUP5 RAV1 VMA6 STV1 VPH1 | 6 | 47 |
cation transport (H+, Na+, K+, Ca2+, NH4+, etc.) [20.01.01.01] | 0.0007315 | VMA2 CUP5 TOK1 MNR2 VMA6 STV1 VPH1 | 7 | 68 |
siderophone-iron transport [20.01.01.01.01.01] | 0.002052 | FTH1 AFT1 FET3 | 3 | 12 |
homeostasis of metal ions (Na, K, Ca etc.) [34.01.01.01] | 0.006003 | FTH1 CUP5 AFT1 TOK1 MNR2 MAC1 FET3 | 7 | 98 |
transport ATPases [20.03.22] | 0.00621 | VMA2 CUP5 VMA6 STV1 VPH1 | 5 | 53 |
metabolism of secondary products derived from L-lysine, L-arginine and L-histidine [01.20.31] | 0.006963 | JJJ3DPH2 | 2 | 6 |
endocytosis [20.09.18.09.01] | 0.009743 | FTH1 RVS161 CUP5 YPK1 WHI2 | 5 | 59 |