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Table 1 Functional categories overrepresented with proteins whose absence renders cells more sensitive to NiSO4.

From: A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae

MIPS Functional Category p-value In Category from Cluster # Nickel Toxicity Modulating Total in Category
homeostasis of proteins [34.01.01.03] 0.000556 VMA2 CUP5 RAV1 VMA6 STV1 VPH1 6 47
cation transport (H+, Na+, K+, Ca2+, NH4+, etc.) [20.01.01.01] 0.0007315 VMA2 CUP5 TOK1 MNR2 VMA6 STV1 VPH1 7 68
siderophone-iron transport [20.01.01.01.01.01] 0.002052 FTH1 AFT1 FET3 3 12
homeostasis of metal ions (Na, K, Ca etc.) [34.01.01.01] 0.006003 FTH1 CUP5 AFT1 TOK1 MNR2 MAC1 FET3 7 98
transport ATPases [20.03.22] 0.00621 VMA2 CUP5 VMA6 STV1 VPH1 5 53
metabolism of secondary products derived from L-lysine, L-arginine and L-histidine [01.20.31] 0.006963 JJJ3DPH2 2 6
endocytosis [20.09.18.09.01] 0.009743 FTH1 RVS161 CUP5 YPK1 WHI2 5 59