Table 2 List of top 10 down-regulated genes in mammary tissue due to IMI with Streptococcus uberis1.
Gene Symbol | Gene Name | Primary Functions | Fold Change |
|---|---|---|---|
LPL | Lipoprotein lipase | Lipoprotein hydrolysis to allow fatty acid uptake | -1.98* |
CD36 | CD36 molecule | Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. | -1.91* |
LPIN1 | Lipin 1 | Triglyceride synthesis; PPAR co-activator | -2.30* |
TRAF3IP3 | TNF receptor-associated factor 3 interacting protein | Primary functions unknown; Play role in cell growth via modulation of JNK pathway; Proapoptosis | -2.25 |
SLC30A4 | Solute carrier family 30, (zinc transporter), member 4 | Transport zinc out of the cytoplasm. | -1.91 |
SLC31A1 | Solute carrier family 31, (copper transporter), member 1 | Copper ion transmembrane transporter. | -1.76 |
KRT19 | Keratin 19 | Involved in structural integrity of epithelial cells. | -1.73 |
PEG3 | Paternally expressed 3 | Nucleic acid binding; Transcription factor activity; Zinc ion binding; Metal ion binding. | -1.71 |
IGF2BP2 | Insulin-like growth factor 2 mRNA binding protein 2 | Functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. | -1.71 |
BTN1A1 | Butyrophilin, subfamily 1, member A1 | Butyrophilin is major protein associated with milk fat droplet. | -1.68 |