Table 3 Top signaling and canonical pathways from Ingenuity Pathways Analysis (IPA) among the 2,102 DEG1.
Ingenuity Canonical Pathways | P-value | Ratio | Genes | ↑/↓ | Effect | Function (from IPA) |
|---|---|---|---|---|---|---|
Signaling pathways | ||||||
ERK/MAPK Signaling | 7E-09 | 0.26 | 50 | 33/17 | ↓ | Induce growth and differentiation |
IL-10 Signaling | 8E-08 | 0.35 | 25 | 22/3 | ⇑ | Limit and terminate the inflammatory |
Glucocorticoid Receptor Signaling | 1E-07 | 0.21 | 61 | 42/17 | ↓ | Regulate immune, metabolic, cardiovascular and behavioral functions |
IL-6 Signaling | 2E-05 | 0.28 | 27 | 24/3 | ⇑ | Regulator of acute-phase responses and a lymphocyte stimulatory factor |
Ceramide Signaling | 2E-05 | 0.29 | 26 | 16/8 | ⇓ | Regulation of apoptosis and inflammation |
Ephrin Receptor Signaling | 3E-05 | 0.21 | 40 | 23/17 | ⇓ | Axon guidance, cell migration, angiogenesis and synaptic plasticity |
PI3K/AKT Signaling | 3E-05 | 0.23 | 31 | 22/9 | ⇓ | Pathways of cytokines, growth factors and other extracellular matrix proteins |
PDGF Signaling | 5E-05 | 0.28 | 22 | 15/7 | ↑ | Growth, survival and function especially in connective tissue |
Axonal Guidance Signaling | 1E-04 | 0.17 | 67 | 39/28 | ⇓ | Help navigate the axon to its final destination |
Chemokine Signaling | 2E-04 | 0.28 | 21 | 11/10 | ⇓ | Act through cell surface receptors to induce inflammation and many processes |
Acute Phase Response Signaling | 2E-04 | 0.21 | 36 | 31/5 | ⇑ | Inflammatory response |
LXR/RXR Activation | 2E-04 | 0.24 | 20 | 14/6 | ⇓ | Mediate the biological effects of retinoids on lipid metabolism and inflammation |
fMLP Signaling in Neutrophils | 2E-04 | 0.21 | 27 | 17/10 | ⇓ | Regulate many neutrophil functions such as migration and phagocytosis |
Aryl Hydrocarbon Receptor Signaling | 2E-04 | 0.21 | 34 | 16/16 | ↓ | Xenobiotic metabolism, cycle progression, cell proliferation, and apoptosis |
PPARa/RXRaActivation | 2E-04 | 0.20 | 37 | 21/16 | ⇓ | Fatty acid metabolism and anti-inflammatory |
IL-3 Signaling | 3E-04 | 0.27 | 20 | 11/9 | ↑ | Regulates hematopoiesis |
CDK5 Signaling | 4E-04 | 0.25 | 23 | 15/8 | ⇓⇓ | Post-mitotic processes such as neuronal activity, migration, and neurite outgrowth |
Apoptosis Signaling | 4E-04 | 0.25 | 25 | 14/9 | ↔ | Apoptosis of programmed cell death |
IGF-1 Signaling | 4E-04 | 0.24 | 23 | 12/11 | ⇓⇓ | Promotes cell proliferation, growth and survival |
Recognition of Bacteria and Viruses | 5E-04 | 0.24 | 21 | 17/4 | ⇑ | Recognize conserved microbial structures or pathogen-associated molecular patterns |
Metabolic pathways | ||||||
Nicotinate and Nicotinamide | 2E-02 | 0.14 | 18 | 9/9 | ⇓ | Synthesis and oxidation/reduction of NADH/NADPH |
Pyruvate | 2E-02 | 0.10 | 17 | 9/6 | ↓ | |
Arginine and Proline | 4E-02 | 0.08 | 14 | 9/5 | ↔ |