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Table 1 The conserved motifs of PC homologues

From: Novel motifs distinguish multiple homologues of Polycomb in vertebrates: expansion and diversification of the epigenetic toolkit

Conserved motif Present in Size(aa) Secondary structure Function
Chromodomain All 61 Twisted antiparallel β sheet (3 β strands and a helix) Binds with H3K27me3
P olyc omb R epressor (PcR) box All 29-31 β strand Interacts with dRING
AT-Hook CBX2 29 Coils DNA binding
AT-Hook Like (ATHL) CBX4, CBX6, CBX7 and CBX8 15 Coils Present in several nuclear proteins (DNA binding?)
CX 2.1 CBX2 69-74 Coils -
CX 2.2 CBX2 25 Coils -
CX 4.1 CBX4 84-88 Coils -
CX 4.2 CBX4 29 Coils -
CX 4.3 CBX4 20 Coils SUMO binding
CX 4.4 CBX4 31 Coils -
CX 6.1 CBX6 82-88 Coils -
CX 6.2 CBX6 36 Coils -
CX 6.3 CBX6 15 Coils -
CX 8.1 CBX8 39-42 Coils -
Poly histidine site Insect PC CBX4 of mammals 6-11 10-14 Coils -
RED repeat CBX8 of mammals 13-37 Coils Present in several proteins
CtBP interaction motif CBX4 5 Coils CtBP binding
Sumoylation site CBX4 (Except fishes) 4-5 Coils Sumoylation
Serine rich region (SRR) CBX2 CBX6 23-38 4-6 Coils -
C onserved I nsect Pc box (CIPC) Insect PC 25-29 Coils Present in insect Polycomb
  1. The multiple sequence alignments of the conserved motifs are given in Additional file 5.