TY - JOUR AU - Wang, Jun AU - Lin, Min AU - Crenshaw, Andrew AU - Hutchinson, Amy AU - Hicks, Belynda AU - Yeager, Meredith AU - Berndt, Sonja AU - Huang, Wen-Yi AU - Hayes, Richard B. AU - Chanock, Stephen J. AU - Jones, Robert C. AU - Ramakrishnan, Ramesh PY - 2009 DA - 2009/11/28 TI - High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays JO - BMC Genomics SP - 561 VL - 10 IS - 1 AB - Single nucleotide polymorphisms (SNPs) have emerged as the genetic marker of choice for mapping disease loci and candidate gene association studies, because of their high density and relatively even distribution in the human genomes. There is a need for systems allowing medium multiplexing (ten to hundreds of SNPs) with high throughput, which can efficiently and cost-effectively generate genotypes for a very large sample set (thousands of individuals). Methods that are flexible, fast, accurate and cost-effective are urgently needed. This is also important for those who work on high throughput genotyping in non-model systems where off-the-shelf assays are not available and a flexible platform is needed. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-10-561 DO - 10.1186/1471-2164-10-561 ID - Wang2009 ER -