Figure 4
From: Robustness of transcriptional regulatory program influences gene expression variability
Fragile transcriptional regulatory program is a major source of expression variability. (A) Average nucleosome profiles in promoter regions are shown for fragile genes (red) and OPN genes (cyan). OPN genes have higher nucleosome occupancy close to the TSS. (B) Comparison of transcriptional plasticity was performed between fragile genes (red) and OPN genes (cyan). Values were normalized, such that their means are zero and standard deviations are one. When removing the genes that are shared by fragile genes and OPN genes, the difference became more significant and OPN genes have transcriptional plasticity comparable to genome-wide level. (C) Multiple regression analysis of two properties influencing seven measures for expression variability, including stochastic noise (stn), responsiveness (res), stress response (str), trans variability (trv), mutational variance (muv), interstrain variation (isv) and expression divergence (div). The effects of fragile transcriptional regulatory program (purple) and the presence of nucleosomes close to the TSS (green) on expression variability were estimated by multiple linear regression of the two properties. Error bars in B and C were calculated by bootstrapping.