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Figure 5 | BMC Genomics

Figure 5

From: Robustness of transcriptional regulatory program influences gene expression variability

Figure 5

A model for robust and fragile transcriptional regulatory programs. Pol II density over the ORF indicates expression level. In the robust transcriptional regulatory program, cooperative TFs work together in an activity-redundant fashion under normal growth condition (the left top panel). Accordingly, the expression level of the robust gene is not affected by stress-related TF binding or TF perturbation (knockout, sequence divergence, activity changes) (the right top two panels). While in the fragile transcriptional regulatory program, cooperative TFs work in an activity-independent fashion under normal growth condition (the left bottom panel). This leads to the expression level of the fragile gene sensitive to stress-related TF binding and TF perturbation (the right bottom two panels).

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