Figure 5

Common gene expression responses to aging in the laboratory mouse. Common gene expression responses to aging are ranked according to the number of tissue types in which genes were (A) significantly up regulated with age or (B) significantly down regulated with age. Genes shown in part (C) were not identified as common responses to aging, but have previously been associated with aging in mammals. Symbols shown within the grid have the same interpretation as those in Figure 2 (with p-values based upon a comparison-wise type I error rate of 0.05), except aging is the experimental factor (rather than CR). Additional File 10 provides a more comprehensive list of genes significantly regulated by aging across tissues, with genes ranked by p-values generated from Fisher's method.