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Table 1 Translocation breakpoints mapped to fragile sites in both partner genes of recurrent cancer-specific translocations

From: Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites

 

5'-b

3'-b

 

Translocationa

Gene

Fragile Site

Gene

Fragile Site

Cancerc

t(2;18)(p11;q21)

BCL2

FRA18B

IGK@

FRA2L

Diffuse large B-cell lymphoma

t(16;16)(p13;q22), inv(16)(p13q22)

CBFB

FRA16B, FRA16C

MYH11

FRA16A

Acute myeloid leukemia

inv(10)(q11q21)

CCDC6

FRA10C

RET

FRA10G

Papillary thyroid carcinoma

t(11;19)(q13;p13)

CCND1

FRA11H

FSTL3

FRA19B

Chronic lymphocytic leukemia

t(2;7)(p11;q21)

CDK6

FRA7E

IGK@

FRA2L

B-cell lymphoma, Chronic lymphocytic leukemia

t(7;11)(q21;q23)

CDK6

FRA7E

MLL

FRA11B, FRA11G

Acute lymphoblastic leukemia

t(5;7)(q35;q21)

CDK6

FRA7E

TLX3

FRA5G

Acute lymphoblastic leukemia

t(12;22)(q13;q12)

EWSR1

FRA22B

ATF1

FRA12A

Soft tissue tumor

t(2;22)(q33;q12)

EWSR1

FRA22B

CREB1

FRA2I

Angiomatoid fibrous histiocytoma

inv(22)(q12q12)

EWSR1

FRA22B

PATZ1

FRA22B

Small round cell tumor

t(6;22)(p21;q12)

EWSR1

FRA22B

POU5F1

FRA6H

Undifferentiated bone tumor

t(2;22)(q31;q12)

EWSR1

FRA22B

SP3

FRA2G

Ewing tumor/small round cell tumor

t(11;22)(p13;q12)

EWSR1

FRA22B

WT1

FRA11E

Soft tissue tumor

del(4)(q12q12)d

FIP1L1

FRA4B

PDGFRA

FRA4B

Hypereosinophilic syndrome

inv(6)(p21q21)

HMGA1

FRA6H

LAMA4

FRA6F

Pulmonary chondroid hamartoma

t(3;6)(q27;p21)

HSP90AB1

FRA6H

BCL6

FRA3C

B-cell tumors

t(1;2)(p22;p11)

IGK@

FRA2L

BCL10

FRA1D

B-cell lymphoma

t(2;19)(p11;q13)

IGK@

FRA2L

BCL3

FRA19A

Mature B-cell neoplasm

t(2;3)(p11;q27)

IGK@

FRA2L

BCL6

FRA3C

Mature B-cell neoplasm, Follicular lymphoma

t(2;11)(p11;q13)

IGK@

FRA2L

CCND1

FRA11A, FRA11H

Mature B-cell neoplasm

t(2;18)(p11;q21)

IGK@

FRA2L

FVT1

FRA18B

Follicular lymphoma

t(3;16)(q27;p12)

IL21R

FRA16E

BCL6

FRA3C

Diffuse large B-cell lymphoma

t(11;19)(q13;q13.4)

MALAT1

FRA11H

MHLB1

FRA19A

Undifferentiated embryonal sarcoma

t(6;11)(p21.1;q13)

MALAT1

FRA11H

TFEB

FRA6H

Pediatric renal neoplasm

t(4;11)(q21.3-22.1;q23)

MLL

FRA11B, FRA11G

AFF1

FRA4F

Acute lymphoblastic leukemia, Acute myeloid leukemia

t(2;11)(q11;q23)

MLL

FRA11B, FRA11G

AFF3

FRA2A

Acute lymphoblastic leukemia

t(5;11)(q31;q23)

MLL

FRA11B, FRA11G

AFF4

FRA5C

Acute lymphoblastic leukemia

del(11)(q23q23)d

MLL

FRA11B, FRA11G

ARHGEF12

FRA11B, FRA11G

Acute myeloid leukemia

t(11;11)(q13;q23)

MLL

FRA11B, FRA11G

ARHGEF17

FRA11H

Acute myeloid leukemia

del(11)(q23q23)d

MLL

FRA11B, FRA11G

CBL

FRA11B, FRA11G

Acute myeloid leukemia

t(11;19)(q23;p13)

MLL

FRA11B, FRA11G

ELL

FRA19B

Acute myeloid leukemia

t(11;22)(q23;q13)

MLL

FRA11B, FRA11G

EP300

FRA22A

Acute myeloid leukemia

t(1;11)(p32;q23)

MLL

FRA11B, FRA11G

EPS15

FRA1B

Acute myeloid leukemia

t(6;11)(q21;q23)

MLL

FRA11B, FRA11G

FOXO3A

FRA6F

Acute myeloid leukemia

t(3;11)(q25;q23)

MLL

FRA11B, FRA11G

GMPS

FRA3D

Acute myeloid leukemia

t(11;14)(q23;q23)

MLL

FRA11B, FRA11G

GPHN

FRA14B

Acute myeloid leukemia

t(11;19)(q23;p13.3)

MLL

FRA11B, FRA11G

MLLT1

FRA19B

Acute myeloid leukemia

t(1;11)(q21;q23)

MLL

FRA11B, FRA11G

MLLT11

FRA1F

Acute myeloid leukemia

t(9;11)(p21;q23)

MLL

FRA11B, FRA11G

MLLT3

FRA9A, FRA9C

Acute myeloid leukemia

t(11;19)(q23;p13)

MLL

FRA11B, FRA11G

MYO1F

FRA19B

Acute myeloid leukemia

inv(11)(q14q23)

MLL

FRA11B, FRA11G

PICALM

FRA11F

Acute myeloid leukemia

t(2;11)(q37;q23)

MLL

FRA11B, FRA11G

SEPT2

FRA2J

Acute myeloid leukemia

t(11;19)(q23;p13)

MLL

FRA11B, FRA11G

SH3GL1

FRA19B

Acute myeloid leukemia

t(6;11)(q13;q23)

MLL

FRA11B, FRA11G

SMAP1

FRA6D

Acute myeloid leukemia

t(10;11)(q21;q23)

MLL

FRA11B, FRA11G

TET1

FRA10C

Acute myeloid leukemia

t(9;9)(p21;p21)

MTS2

FRA9A, FRA9C

MTS1

FRA9A, FRA9C

Acute lymphoblastic leukemia

inv(10)(q11q11)

NCOA4

FRA10G

RET

FRA10G

Papillary thyroid carcinoma

t(3;5)(q25;q35)

NPM1

FRA5G

MLF1

FRA3D

Acute myeloid leukemia

t(3;6)(q27;p21)

PIM1

FRA6H

BCL6

FRA3C

Diffuse large B-cell lymphoma

t(3;6)(q27;p21)

SFRS3

FRA6H

BCL6

FRA3C

Follicular lymphoma

t(19;19)(p13;q13)

TCF3

FRA19B

TFPT

FRA19A

Acute lymphoblastic leukemia

inv(1)(q21q31)

TPM3

FRA1F

TPR

FRA1K

Papillary thyroid carcinoma

  1. aThe translocation names for each unique gene set are indicated.
  2. bPosition in which the gene appears in the cancer-specific fusion transcript
  3. cFor a complete description, see the Mitelman database of Chromosome Aberrations in Cancer [27].
  4. dDeletions creating a fusion between two genes