Figure 3

TF→miRNA associations and their inferred Pearson correlation coefficients. A/ Depicted is the number of TF→miRNA associations that have a score equal or greater then specific PCC s. The blue blocks indicate the number of associations that have a positive PCC greater or equal to the positive value indicated on the x-axis. The red blocks indicate the number of associations with a negative PCC smaller or equal to the negative value indicated on the x-axis. As expected, the number of associations steadily decreases with increasing absolute PCC. B/ Depicted is the distribution of the absolute value of the calculated PCCs for all 1,989 TF→miRNA associations. The red line indicates the cut-off value that was utilised to select the top quartile of the associations. The distribution is not normal distributed, but skewed towards higher PCCs resulting from the chosen method of time-shifts, which favours higher PCCs over lower ones.