The iron/heme regulated genes of Haemophilus influenzae: comparative transcriptional profiling as a tool to define the species core modulon

Table 4 ArcA/FeHm regulated operons in H. influenzae

		Fold Change^c
Gene^a	Description^b	NTHi R2866	Hib 10810	Hi Rd KW20
Down regulated Δ *arcA*
HI0590	potE	-12.75	-5.99	-3.20
HI0591	speF	-11.40	-13.78	-3.82
HI0592	Conserved hypothetical protein	ns	ns	ns
HI1349	DPS-Ferritin	-4.12	-3.70	-1.54
Up regulated Δ *arcA*
HI0007	Formate dehydrogenase beta subunit fdxH	7.49	6.00	3.40
HI0008	Formate dehydrogenase gamma subunit fdxI	7.47	5.23	3.20
HI0009	FdhE	3.35	3.43	1.88
HI0018	Uracil DNA glycosylase ung	ns	ns	ns
HI0026	Lipoate biosynthesis protein A lipA	3.19	2.00	ns
HI0174	tRNA methyltransferase	2.36	2.08	1.93
HI0608	Conserved hypothetical protein	ns	-1.54	-1.49
HI0747	NADH dehydrogenase ndh	ns	ns	ns
HI0889	Serine methylase glyA	1.83	1.68	-1.09
HI0890	Dephospho CoA kinase coaE	2.50	3.48	ns
HI1218	L-lactate permease lldP	4.67	3.58	ns
HI1444	5,10 methlyenetetrahydrofolate reductase metF	5.19	3.47	ns
HI1661	2-oxoglutarate dehydrogenase E2 sucB	1.56	1.17	-1.18
HI1662	2-oxoglutarate dehydrogenase E1 sucA	ns	ns	-1.18
HI1727	Argininosuccinate synthetase argG	-2.28	ns	ns
HI1728	Conserved hypothetical protein	ns	1.59	ns
HI1730	Conserved hypothetical protein	ns	1.53	ns
HI1731	Conserved hypothetical protein	ns	2.35	ns
HI1739	L-lactate dehydrogenase lldD	1.55	1.63	ns

^a. Gene locus. For genes with homologues in Rd KW20 the corresponding Rd KW20 gene locus is given.
^b. Name and description of the gene, where known, based on annotation
^c. Fold change determined from the microarray data. ns, Non significant

ISSN: 1471-2164