Linking mechanistic and behavioral responses to sublethal esfenvalerate exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae)

Connon, Richard E; Geist, Juergen; Pfeiff, Janice; Loguinov, Alexander V; D'Abronzo, Leandro S; Wintz, Henri; Vulpe, Christopher D; Werner, Inge

doi:10.1186/1471-2164-10-608

Table 1 Classification of differential gene expression of esfenvalerate responding genes in 52-d old H. transpacificus following 24 h exposure as identified by microarray analyses.

From: Linking mechanistic and behavioral responses to sublethal esfenvalerate exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae)

BLASTX top hit	Species match	Accession No.	Score	E-value	Concentration	Fold Change (+/-)	P-VALUE (or cut-off)
Neuromuscular
titin a	Danio rerio	ABG48500	110	4.00E-23	0.0625	1.3277	0.0625	**
smooth muscle cell-specific protein SM22 alpha	Epinephelus coioides	ABW04145	349	1.00E-94	0.1250	1.2252	0.0029
toxin-1	Oncorhynchus mykiss	AAM21198	116	5.00E-25	0.1250	1.1884	0.0044
thymosin beta-12	Lateolabrax japonicus	P33248	80	2.00E-13	0.1250	1.1876	0.0003
similar to 19.9 kD myosin light chain isoform 1	Danio rerio	XP_685183	332	1.00E-89	0.1250	1.1720	0.0046
ictacalcin	Ictalurus punctatus	AAY86967	145	1.00E-33	0.1250	1.1607	0.0021
tropomyosin	Theragra chalcogramma	BAC44994	281	2.00E-74	0.1250	1.1368	0.0090
N-acylsphingosine amidohydrolase	Takifugu rubripes	AAM43813	367	e-100	0.1250	1.1196	0.0082
alanine-glyoxylate aminotransferase	Platichthys flesus	CAH59400	345	2.00E-93	0.1250	1.0860	0.0059
titin b	Danio rerio	ABG48499	65	5.00E-09	0.1250	-1.0841	0.0045
alpha-2,8-polysialyltransferase IV	Oncorhynchus mykiss	BAC77411	70	1.00E-10	0.1250	-1.0878	0.0030
hedgehog acyltransferase-like, a	Danio rerio	NP_957181	295	1.00E-78	0.1250	-1.1419	0.0074
parvalbumin	Cyprinus carpio	CAC83659	173	7.00E-42	0.1250	-1.1675	0.0033
BTEB transcription factor	Pimephales promelas	ABO28528	107	1.00E-21	0.0625	-1.2019	0.0625	*
myosin regulatory light chain 2	Salmo salar	CAD89610	330	7.00E-89	0.1250	-1.2121	0.0020
similar to Clca1 protein	Danio rerio	XP_694323	198	2.00E-49	0.0625	-1.2547	0.0625	*
ependymin	Perca flavescens	ABU49423	168	2.00E-40	0.0625	-1.2602	0.0625	*
aspartoacylase	Danio rerio	NP_001103573	384	e-105	0.0625	-1.3905	0.0625	*
Immune
carboxypeptidase B	Paralichthys olivaceus	BAC53789	365	2.00E-99	0.1250	1.2897	0.0041
fish-egg lectin (FEL)	Cyprinus carpio	P68512	192	2.00E-47	0.1250	1.1769	0.0003
procathepsin B	Oncorhynchus mykiss	AAK69705	346	1.00E-93	0.0625	-1.1727	0.0625	*
gamma-glutamyl hydrolase	Danio rerio	NP_998487	223	6.00E-57	0.0625	-1.1939	0.0625	*
membrane glycoprotein	Human coronavirus	ABD75532	53	1.00E-05	0.0625	-1.1945	0.0625	*
beta-2 microglobulin	Salmo salar	AAG17525	176	8.00E-43	0.1250	-1.1995	0.0034
microtubule-associated protein 1 light chain 3 alpha	Danio rerio	NP_999904	238	3.00E-61	0.0625	-1.2245	0.0625	*
microtubule-associated protein, RP/EB family, member	Danio rerio	NP_998805	272	1.00E-71	0.0625	-1.2298	0.0625	*
T-cell receptor beta chain ANA 11, putative	Brugia malayi	EDP38115	63	2.00E-08	0.1250	-1.2600	0.0052
glycerophosphodiester phosphodiesterase domain containing 1	Danio rerio	NP_001004118	322	2E-86	0.0625	-1.2652	0.0625	*
CHK1 checkpoint homolog	Xenopus tropicalis	CAJ83813	92	2.00E-17	0.1250	-1.3981	0.0013
Apoptosis
tissue inhibitor of metalloproteinase 2	Oncorhynchus mykiss	AAU14867	265	3.00E-69	0.1250	1.1235	0.0082
cathepsin H	Danio rerio	NP_997853	300	5.00E-80	0.1250	1.0898	0.0069
caspase-3	Dicentrarchus labrax	ABC70996	223	6.00E-68	0.1250	-1.0647	0.0022
caspase-1	Dicentrarchus labrax	ABB05054	79	3.00E-13	0.1250	-1.1270	0.0061
cathepsin S-like	Oncorhynchus mykiss	AAV32964	291	1.00E-77	0.1250	-1.1507	0.0047
Redox and metal ion binding
hydroxymethylbilane synthase	Danio rerio	CAM15096	369	e-101	0.1250	1.3333	0.0042
hemopexin	Danio rerio	NP_001104617	313	2.00E-83	0.1250	1.2968	0.0052
transferrin	Salvelinus fontinalis	BAA84100	326	1.00E-87	0.1250	1.1769	0.0080
similar to leprecan-like 1 protein	Danio rerio	XP_695073	183	1.00E-44	0.1250	1.1543	0.0036
similar to synaptic glycoprotein SC2	Danio rerio	XP_693420	430	e-119	0.1250	-1.1340	0.0073
similar to LOC407663 protein	Danio rerio	XP_698537	124	6.00E-27	0.0625	-1.2429	0.0625	*
Growth and development
yghl1 (Putative growth hormone like protein-1)	Seriola quinqueradiata	BAB62526	153	1.00E-35	0.1250	-1.1388	0.0072
ZPA domain containing protein	Oryzias latipes	NP_001098216	168	3.00E-40	0.0625	-1.1568	0.0625	*
Detoxification
pregnane × receptor	Oncorhynchus mykiss	ABP38412	206	2.00E-51	0.0625	-1.2321	0.0625	*
Osmotic stress
hyperosmotic glycine rich protein	Salmo salar	AAO32675	134	8.00E-30	0.1250	-1.1053	0.0021
Digestion
similar to Apoa4 protein isoform 2 (Apolipoprotein)	Danio rerio	XP_698920	296	7.00E-79	0.1250	1.4959	0.0056
chymotrypsinogen 2-like protein	Sparus aurata	AAT45254	460	e-128	0.1250	1.4211	0.0095
pancreatic carboxypeptidase A1 precursor copy 2	Tetraodon nigroviridis	AAR16321	242	9.00E-63	0.1250	1.3204	0.0025
pancreatic protein with two somatomedin B domains	Paralichthys olivaceus	BAA88246	214	e-100	0.1250	1.1297	0.0021
chitinase (Zgc:55941)	Danio rerio	AAH44549	369	e-100	0.1250	-1.0618	0.0097

Genes selected for quantitative PCR analyses are shown in bold. * indicates genes responding at 0.0625 μg.L^-1 esfenvalerate and ** indicates gene responding to both 0.0625 and 0.125 μg.L¹ esfenvalerate. Remaining genes responded only at 0.125 μg.L¹ esfenvalerate exposure. Information represents proportions of a limited number of available genes on the applied microarray.

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