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Figure 3 | BMC Genomics

Figure 3

From: Revisiting the missing protein-coding gene catalog of the domestic dog

Figure 3

D N / d S cumulative frequency distribution of references, gene predictions and pseudogene predictions sets. Benchmark, predicted genes, pseudogenes (with one mutation) and pseudogenes (with accumulated mutations) sets exhibit a median dN/dS of 0.15, 0.18, 0.22, 0.47, respectively, compared to their human functional orthologues. While the dN/dS distribution of pseudogenes with accumulated mutations sets is clearly shifted upwards to the theoretical value of 0.57 (average between 1.0 for no selection and 0.15 for selection from the benchmark set), the pseudogene set with one mutation is not significantly shifted suggesting this set may contains spurious pseudogene prediction. Predicted and benchmark gene sets have a similar dN/dS cumulative frequency distribution indicating comparable selective constraints level.

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