distributions of benchmark and test sets. A. The dN/dS distribution (as log dN/dS) of the test set (new predicted genes) is represented in purple and benchmark set (human-dog 1:1 orthologous) is represented in blue. Test set exhibits a dN/dS distribution similar to the benchmark set (Mann-Whitney; P = 0.16) suggesting comparable selective constraints for both sets. B. In contrast the dN/dS distribution of the pseudogene (with accumulated mutations) set (red) is significantly shifted upwards (Mann-Whitney; P = 5.17e - 6) in comparison to the benchmark set, indicating relaxation of selective constraints on the predicted pseudogenes.