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Table 2 Differential expression pattern at pH 6 in comparison to pH 7.5

From: Functional genomics of pH homeostasis in Corynebacterium glutamicum revealed novel links between pH response, oxidative stress, iron homeostasis and methionine synthesis

Genes induced at pH 6   Transcriptome4 Proteome5 Regulators6
         cytoplasm envelope membrane  
No gene ID1 op2 gene function TMH3 pH 6 pH 9 6 7.5 9 6 7.5 9 6 7.5 9  
1 cg0012    Hypothetical protein 0 1.45 n.d. - - - 2.5 - - - - - McbR*
2 cg0325    Multisubunit Na+/H+ antiporter 2 1.04 0.17 - - - 0.6 1.3 0.8 - - -  
3 cg0360    Putative phosphatase 1 1.35 n.d. - - - - - - - - -  
4 cg0403 b rmlB1 dTDP-glucose 4,6-dehydratase 0 1.04 n.d. - - - - - - - - -  
5 cg0404 b   Nitroreductase family 0 1.77 -1.50 3.4 2.5 0.9 0.9 - - -0.9 - -  
6 cg0550    Putative peptidase E 0 1.10 -0.46 - - - - - - - - -  
7 cg0736 k metN ATPase component 0 1.45 n.d. 2.2 - - 5.1 2.8 2.6 4.0 1.7 -0.6 McbR*, RamB*
8 cg0737 k metQ periplasmic component 0 1.85 -0.69 5.4 3.4 3.5 7.2 4.1 4.7 9.1 6.8 6.7 McbR*, RamB*
9 cg0754 l metX Homoserine O-acetyltransferase 0 1.19 n.d. 2.1 - -0.8 2.5 - -0.3 - - - McbR*
10 cg0755 l metY O-acetylhomoserine sulfhydrylase 0 2.43 -0.08 6.6 4.8 5.4 3.3 0.7 1.4 1.7 - - McbR*
11 cg0874    Uncharacterized ACR, COG2135 0 1.03 0.46 - - - -0.4 - - - - -  
12 cg0878   whiB1 Stress response transcription factor WhiB1 0 1.26 0.49 - - - - - - - - - SigH, GlxR*
13 cg1081 p   ABC-type multidrug transport system, ATPase component 0 1.18 0.86 -0.3 -0.8 0.0 2.0 2.6 3.3 3.0 3.3 4.4  
14 cg1082 p   ABC-type multidrug transporter, permease components 6 1.33 0.68 - - - - - 1.4 - - -  
15 cg1083 p cgtS10 Two-component system, sensory transduction histidine kinases 5 1.38 0.64 - - - - - 1.0 - - - SigB*
16 cg1129   aroG Phospho-2-dehydro-3-deoxyheptonate aldolase 0 1.44 n.d. 1.1 1.5 - 2.4 2.6 - -0.7 1.4 -  
17 cg1150    NADPH dependent FMN reductase 0 1.02 n.d. 1.2 - - - - - - - -  
18 cg1202    Hypothetical protein 0 1.23 n.d. - - - - - - - - -  
19 cg1214 q sufS Cysteine desulfurase involved in maturation of Fe-S clusters 0 1.30 -0.37 -0.6 - - 1.4 -0.3 - - - - NrtR*
20 cg1215 q nadC Nicotinate-nucleotide pyrophosphorylase 0 1.30 -0.06 5.1 4.2 3.6 1.2 - - 2.1 - 1.6 NrtR*
21 cg1216 q nadA Quinolinate synthetase A 0 1.77 -0.20 - 0.2 0.7 2.2 2.6 - - 0.7 - NrtR*
22 cg1218 q nrtR Regulator NrtR, ADP-ribose pyrophosphatase 0 1.58 -0.24 - - - - - - - - - NrtR*
23 cg1256   dapD Tetrahydrodipicolinate N-succinyltransferase 0 1.25 n.d. 2.5 0.4 - 5.0 3.6 2.4 -0.9 - -  
24 cg1291    Hypothetical membrane protein 2 2.43 n.d. - - - 0.9 - - - - -  
25 cg1322    Uncharacterized beta barrel protein 0 1.24 -0.62 6.3 5.1 2.7 - - - 2.6 -0.6 -  
26 cg1337   hom Homoserine dehydrogenase 0 1.68 0.22 4.4 2.4 3.0 5.4 4.5 4.0 3.1 3.2 1.4 McbR
27 cg1344 s narG Nitrate reductase 0 1.36 1.94 - - -0.6 - - - - - -0.4 RipA, GlxR*
28 cg1476   thiC Thiamine biosynthesis protein 0 1.00 0.62 3.9 3.8 4.1 2.9 2.3 3.6 1.8 1.4 1.0  
29 cg1478    Hypothetical protein 0 4.89 n.d. -0.6 - - - - - - - - LexA
30 cg1580 v argC N-acetyl-gamma-glutamyl-phosphate reductase 0 1.65 -0.17 2.9 2.2 2.2 1.3 -0.2 - -0.9 - - ArgR
31 cg1581 v argJ Glutamate N-acetyltransferase 0 2.03 -0.02 5.8 5.0 5.2 2.8 2.1 2.1 - - - ArgR
32 cg1582 v argB Acetylglutamate kinase 0 1.84 n.d. 1.1 - -0.8 3.1 - 0.0 - - - ArgR
33 cg1583 v argD Acetylornithine aminotransferase 0 1.66 n.d. 1.9 0.9 0.2 - - - - - - ArgR
34 cg1584 v argF Ornithine carbamoyltransferase 0 1.75 -0.12 1.2 0.4 -0.2 - - - - - - ArgR
35 cg1586 v argG Argininosuccinate synthase 0 1.16 0.05 4.1 4.3 4.3 5.4 5.2 5.1 3.1 3.5 2.8  
36 cg1626 w   Hypothetical secreted protein 0 2.12 n.d. - - - - - - - - -  
37 cg1628 w   Putative hydrolase 0 2.25 n.d. - - - 1.9 - - - - -  
38 cg1647    ABC-type multidrug transporter, permease components 5 1.06 -0.01 - - - -0.4 - -0.3 - - - AmtR*
39 cg1701   metH Homocysteine Methyltransferase 0 2.22 0.12 1.1 - - 3.7 3.1 0.7 - - -0.6 McbR*
40 cg1739    GMP synthase-Glutamine amidotransferase domain 0 1.36 n.d. - - - - - - - - - McbR*
41 cg1806   metK S-adenosylmethionine synthetase 0 1.29 -0.17 2.9 2.3 1.1 3.6 2.9 - - - - McbR
42 cg1940    Hypothetical protein 1 1.18 -0.08 - - - - - - - - -  
43 cg2051    Hypothetical protein 0 1.25 n.d. - - - - - - - - -  
44 cg2157   terC putative tellurium exporter TerC 9 1.05 -0.13 - - - 2.8 2.4 1.5 1.5 1.0 2.3  
45 cg2250    Hypothetical protein 0 1.16 n.d. - - - 0.6 - -0.3 1.6 - 1.1  
46 cg2260   glnK Nitrogen regulatory protein PII 0 1.13 n.d. 1.2 2.2 1.4 - - - - - - AmtR
47 cg2338   dnaE1 DNA polymerase III, alpha chain 0 1.12 0.29 - - - 0.0 - -0.3 - - -  
48 cg2380    Hypothetical membrane protein 2 1.00 0.12 - - - 1.7 1.3 0.8 - - -0.6  
49 cg2462    TetR-type transcription factor 0 1.12 n.d. - - - - - - - - -  
50 cg2472    Predicted hydrolase or acyltransferase 0 1.14 0.48 - - - - - - - - -  
51 cg2576    DNA polymerase III delta subunit 0 1.17 n.d. - - - - - - - - -  
52 cg2590    Putative xanthine/uracil permease 12 1.87 n.d. - - - - - - 0.2 - -0.6  
53 cg2591   dkgA 2,5-diketo-D-gluconic acid reductase 0 1.72 n.d. 3.2 0.9 2.0 - - - - - -  
54 cg2674 ae   Putative Carboxymuconolactone decarboxylase 0 1.08 -0.25 3.0 2.8 2.5 1.5 - - -0.9 - - McbR*
55 cg2675 ae   ABC-type putative peptide transporter, duplicated ATPase component 0 1.70 n.d. 0.8 -0.4 - 3.9 0.8 - 0.2 - - McbR*
56 cg2677 ae   ABC-type putative peptide transporter, permease subunit 6 2.00 n.d. - - - 3.9 0.8 1.9 2.9 1.6 1.5 McbR*
57 cg2678 ae   ABC-type putative peptide transporter, periplasmic subunit 0 1.90 n.d. 1.2 - -0.2 4.9 1.3 3.4 6.0 3.3 2.7 McbR*
58 cg2687   metB Cystathionine beta-lyases/cysta-thionine gamma-synthases 0 1.34 0.37 5.3 4.2 5.1 - - - - - -0.4 McbR*
59 cg2748    Hypothetical membrane protein 2 1.21 0.86 - - - -0.4 - -0.3 2.7 - 1.8  
60 cg2761    Metal-dependent hydrolases of the beta-lactamase superfamily III 0 1.05 -0.30 0.4 -0.8 - - - - - - -  
61 cg2766    MarA-type transcription factor 0 1.20 0.69 0.7 - 1.5 - -0.3 - - - - RamB*
62 cg2796 af prpD Putative 2-methylcitrate dehydratase 0 2.79 n.d. 4.7 - - 2.0 - - - - - DtxR
63 cg2797 af   Putative 2-phospho-3-sulpholactate synthase 0 2.92 n.d. 2.4 - - - -0.2 - - - - DtxR
64 cg2834   cysE Serine O-Acetyltransferase 0 1.48 n.d. - -0.5 - 3.4 1.3 2.1 0.4 - -  
65 cg2835    Predicted acetyltransferase 0 1.52 0.56 2.5 - 1.9 0.8 - - - - -  
66 cg2890    Putative amino acid processing enzyme 0 2.18 n.d. - - - - - - - - -  
67 cg2891   poxB Pyruvate:quinone oxidoreductase 0 2.02 -0.21 3.6 0.4 0.3 0.6 - 0.9 -0.9 - - SigB*
68 cg3049   fprA putative ferredoxin NADP oxidoreductases 0 1.26 0.24 3.3 3.1 3.6 3.3 3.8 3.0 0.2 2.4 -0.6  
69 cg3082 ag   ArsR-type transcription factor 0 3.34 n.d. - - - - - - - - - DtxR
70 cg3083 ag   Predicted Co/Zn/Cd cation transporter 6 3.42 n.d. - - - 1.2 - - - - - DtxR
71 cg3084 ag   putative FAD dependent NAD(P)H disulphide oxidoreductase 0 3.14 n.d. - - - 2.6 - - - - - DtxR
72 cg3085 ag   putative FAD dependent oxidoreductase 0 1.47 n.d. -0.6 - - - - - - - - DtxR
73 cg3112 ah cysZ Sulfate permease 7 4.03 0.32 - - - 3.8 0.8 2.6 2.6 0.7 1.6 DtxR, McbR*, CysR*
74 cg3113 ah   Putative metal chelatase 0 3.31 n.d. - - - - - - - - - DtxR, McbR*, CysR*
75 cg3114 ah cysN GTPases-Sulfate adenylate transferase subunit 1 0 3.42 0.48 4.4 1.4 3.2 6.2 4.1 4.0 4.6 3.1 1.0 DtxR, McbR*, CysR*
76 cg3115 ah cysD 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase) 0 3.27 0.78 4.4 2.8 3.0 5.5 4.0 3.7 4.2 2.4 1.0 DtxR, McbR*, CysR*
77 cg3116 ah cysH Phosphoadenosine-Phosphosulfate Reductase 0 2.98 n.d. - -0.5 - 2.7 2.3 2.4 - - - DtxR, McbR*, CysR*
78 cg3117 ai cysX Hypothetical protein 0 3.50 1.08 - - - - - - - - - DtxR, McbR*, CysR*
79 cg3118 ai cysI Sulfite reductase hemoprotein beta-component 0 3.50 1.06 0.6 1.5 2.4 3.5 2.1 -0.3 - - - DtxR, McbR, CysR*
80 cg3119   cysJ Probable NADPH-dependent Sulfite Reductase 0 2.99 0.29 4.9 4.2 3.5 2.8 1.3 1.4 2.0 1.4 - DtxR, McbR*, CysR*
81 cg3157    Uncharacterized vancomycin resistance protein 1 1.54 0.23 - - - 2.7 2.1 3.1 3.7 -0.6 -0.4  
82 cg3215   glpQ1 Putative glycerophosphoryl diester phosphodiesterase 0 1.02 n.d. - - - - - - - - -  
83 cg3219   ldh Anaerobic L-lactate DH 0 1.83 0.12 5.1 3.1 4.8 4.3 1.3 2.3 - - -0.4 GlxR*
84 cg3227   lldD Aerobic FMN-L-lactate DH 0 1.14 0.45 1.2 2.1 0.7 5.2 4.1 4.0 1.5 -0.6 - GlxR*
85 cg3236   msrA Methionine sulfoxide reductase 0 1.27 1.01 - - -0.8 - - - - - -  
86 cg3372    Hypothetical membrane protein 0 2.80 -0.16 - - - 1.8 - - -0.7 - - McbR*, CysR*
87 cg3374 ak   Putative NADH-dependent flavin oxidoreductase 0 2.48 n.d. - - - - - - - - - McbR*, CysR*
88 cg3375 ak   Putative NAD dependent dehydratase 0 1.61 n.d. 1.5 -0.8 0.8 - - - - - - McbR*, CysR*
Genes repressed at pH 6
1 cg0148   panC Pantoate--beta-alanine ligase 0 -1.29 -0.56 -0.6 1.7 -0.8 - - - - - -  
2 cg0244 a   Hypothetical membrane protein 4 -1.23 -0.49 - - - - - - - - -  
3 cg0245 a   Putative Moco sulfurase involved in sulphur metal clusters formation 0 -1.02 -0.64 - - - - - - - - -  
4 cg0252    Hypothetical membrane protein 5 -1.16 -0.58 - - - - - - - - -  
5 cg0308    Putative membrane protein 4 -1.34 n.d. - - - - - - - - -  
6 cg0337   whiB4 Transcriptional regulator 0 -1.04 0.39 - - - - - - - - -  
7 cg0350   glxR Transcriptional regulator 0 -1.18 -0.07 4.0 4.7 4.6 3.3 2.8 3.1 -0.7 -0.6 1.5  
8 cg0445 c sdhCD Succinate dehydrogenase CD 5 -1.31 1.31 - - - 1.8 1.4 2.4 3.2 4.0 5.0 RipA, DtxR, RamA*, RamB*
9 cg0446 c sdhA Succinate dehydrogenase A 0 -1.08 1.47 1.0 2.7 1.7 6.7 7.0 9.0 8.5 9.0 9.9 RipA, DtxR, RamA*, RamB*
10 cg0447 c sdhB Succinate dehydrogenase B 0 -1.43 1.14 - -0.4 - 4.6 5.0 6.7 3.5 3.4 5.3 RipA, DtxR, RamA*, RamB*
11 cg0465    Conserved hypothetical membrane protein 3 -1.14 n.d. - - - - -0.2 - - - - DtxR
12 cg0466    Heme transport system, substrate binding subunit 0 -1.33 n.d. - - - - - - - - - DtxR
13 cg0470 d   Heme transport associated protein 2 -1.66 n.d. -0.6 1.9 - 3.5 3.8 - 3.3 3.6 - DtxR, LexA
14 cg0471 d   Heme transport associated protein 1 -1.30 n.d. - - - - -0.3 - 0.1 1.0 - DtxR, LexA
15 cg0493    Hypothetical protein 0 -1.05 -0.41 - - - - - - - - -  
16 cg0563 e rplK 50S ribosomal protein L11 0 -1.28 -0.59 - - - 0.9 0.7 0.8 -0.9 - -0.6  
17 cg0564 e rplA 50S ribosomal protein L1 0 -1.10 -0.57 4.5 5.0 4.8 3.9 4.2 4.0 4.1 4.4 4.5  
18 cg0572 f rplJ 50S ribosomal protein L10 0 -1.60 -0.69 3.4 4.3 3.6 2.1 2.3 2.1 4.2 4.5 3.9  
19 cg0573 f rplL 50S ribosomal protein L7/L12 0 -1.53 -0.59 5.3 5.5 4.5 - 1.3 0.0 0.2 0.4 1.6  
20 cg0582   rpsG 30S ribosomal protein S7 0 -1.07 -0.35 3.1 3.4 2.1 2.2 2.6 3.3 1.3 1.6 1.5  
21 cg0599   rpsS 30S ribosomal protein S19 0 -1.09 -0.51 1.7 2.2 1.1 - - -0.3 - - -  
22 cg0601 g rpsC 30S ribosomal protein S3 0 -1.05 -0.35 3.3 3.2 3.0 4.7 4.0 4.5 0.3 0.4 0.4  
23 cg0602 g rplP Ribosomal protein L16/L10E 0 -1.02 -0.27 3.1 3.3 3.1 4.5 4.8 5.0 3.0 3.4 3.5  
24 cg0603 g rpmC 50S ribosomal protein L29 0 -1.01 -0.20 - -0.8 - - - - - - -  
25 cg0604 g rpsQ 30S ribosomal protein S17 0 -1.18 -0.21 3.3 3.2 2.8 - - 0.0 - - -  
26 cg0623 h   ABC-type cobalt exporter unit 8 -1.05 -1.35 - - - - - - - - -  
27 cg0624 h   Hypothetical membrane protein 2 -1.09 -1.09 - - - - - - 1.3 1.6 -0.4  
28 cg0625 h   Putative terpene cylase or prenyltransferase subunit 1 -1.28 -1.04 - 2.2 0.0 2.8 3.6 2.2 - -0.6 -0.4  
29 cg0690 i groS 10 kDa chaperonin 0 -1.77 -0.02 4.1 4.3 4.7 - - - - - - SigM*
30 cg0691 i groEL 60 kDa chaperonin HSP60 0 -2.19 -0.11 4.0 3.4 3.8 - - - 1.2 -0.6 1.1 SigM*
31 cg0693 i groL1 60 kDa chaperonin1 Hsp60 0 -1.47 0.02 5.6 5.8 5.8 1.8 0.7 1.8 2.5 1.7 1.6  
32 cg0748    ABC-type Fe3+-siderophores transport systems, periplasmic components 0 -1.07 -2.14 -0.3 1.3 - 1.2 0.7 - 0.1 -0.6 - DtxR
33 cg0752    Putative flotillin like protein 1 -1.55 -0.47 0.6 2.7 1.6 3.4 2.3 1.8 4.4 4.7 3.4  
34 cg0760   prpB2 Methylisocitrate lyase 2 0 -1.54 -0.80 - 3.2 0.9 -0.4 0.8 - - - -  
35 cg0762   prpC2 2-methylcitrate synthase 2 0 -1.39 n.d. - 1.7 0.8 - - - - - -  
36 cg0832    ABC-type transporter, permease components 5 -1.33 -0.40 - - - -0.4 - - - 1.0 1.1  
37 cg0834    ABC-type transporter, periplasmic component 0 -2.46 -0.03 1.6 3.4 2.7 2.5 3.6 3.7 2.9 4.2 4.1 LexA
38 cg0842    Putative DNA helicase 0 -1.03 n.d. - - - - - - - - -  
39 cg0898   pdxS Pyridoxal biosynthesis lyase pdxS 0 -1.09 -0.61 4.6 5.0 4.3 - - - -0.7 - - LexA, PdxR
40 cg0952 o mctB putative monocarboxylate transporter subunit 2 -2.55 -1.32 - 0.5 - 2.4 4.7 4.1 - 2.1 -0.6  
41 cg0953 o mctC monocarboxylate transporter 13 -2.44 -1.01 - 3.0 -0.2 1.9 4.7 4.7 3.2 4.5 3.2  
42 cg0961    Homoserine acetyltransferase 0 -1.70 n.d. - - - - - - - - -  
43 cg1072   rplY 50S ribosomal protein L25 0 -1.26 -0.49 0.7 1.1 0.6 - - - - - -0.4  
44 cg1108   porC Putative secreted protein 0 -1.11 0.06 - - - 0.8 2.3 - - 1.0 -  
45 cg1122    Hypothetical protein 0 -1.31 0.23 - -0.8 -0.8 3.3 4.7 6.1 5.8 6.3 6.6  
46 cg1123   greA Transcription elongation factor 0 -1.21 -0.14 2.0 0.4 2.4 - - - - - -  
47 cg1167   metS putative methionine transporter subunit 0 -1.04 -1.43 - - - - - - -0.9 - -0.6  
48 cg1362 t atpB F0F1-type ATP synthase a subunit 6 -1.35 -0.85 - - - 2.7 3.2 3.8 5.8 6.0 5.5 SigH*
49 cg1363 t atpE F0F1-type ATP synthase c subunit 2 -1.60 -0.88 - - - 4.4 5.0 3.6 5.4 6.6 6.4 SigH*
50 cg1364 t atpF F0F1-type ATP synthase b subunit 1 -1.52 -0.96 -0.6 0.5 -0.8 4.5 4.8 4.9 4.9 5.4 4.3 SigH*
51 cg1365 t atpH F0F1-type ATP synthase delta subunit 0 -1.26 -1.03 1.9 2.3 1.3 3.9 4.8 4.7 3.2 4.1 3.4 SigH*
52 cg1366 t atpA F0F1-type ATP synthase alpha subunit 0 -1.65 -0.89 4.9 5.1 5.1 5.6 6.2 6.1 6.8 6.9 6.4 SigH*
53 cg1367 t atpG F0F1-type ATP synthase gamma chain 0 -1.71 -1.11 1.1 4.2 3.4 3.3 4.9 4.7 4.0 4.0 2.5 SigH*
54 cg1368 t atpD F0F1-type ATP synthase beta chain 0 -1.72 -0.94 5.3 5.5 5.4 5.7 5.8 5.6 6.3 6.0 5.7 SigH*
55 cg1369 t atpC F0F1-type ATP synthase epsilon chain 0 -1.09 n.d. 1.6 0.4 0.7 - - -0.1 3.1 2.5 1.9 SigH*
56 cg1436   ilvN Acetolactate synthase, subunit 0 -1.41 -0.69 2.0 2.2 2.4 1.5 3.2 1.5 -0.9 -0.6 -0.6  
57 cg1437   ilvC Ketol-acid reductoisomerase 0 -1.44 -0.91 4.0 3.8 3.9 2.9 3.9 3.3 -0.9 1.7 -0.6  
58 cg1564 u rpmI 50S ribosomal protein L35 0 -1.04 -0.31 - -0.8 - 1.6 1.4 2.4 - - -  
59 cg1565 u rplT 50S ribosomal protein L20 0 -1.26 -0.29 1.2 1.5 -0.2 - -0.2 - - - -  
60 cg1579    Hypothetical protein 0 -1.36 -0.66 - - - - - - - - -  
61 cg1612    Putative acetyltransferases 0 -1.32 n.d. - - - - - - - - -  
62 cg1905 y   Putative protein kinase 0 -1.33 0.72 - - - - 0.7 - - - -  
63 cg1906 y   Putative protein phosphatase 0 -1.17 0.63 - - - - -0.2 - - - -  
64 cg1913    Hypothetical protein 0 -1.19 n.d. - - - - - - - - -  
65 cg1930 z   Putative secreted serine protease 0 -1.18 -3.26 - - - - - - - - - DtxR
66 cg2136 aa gluA ABC-type glutamate transporter, ATPase component 0 -1.36 -0.07 -0.6 -0.5 0.8 1.9 4.3 3.8 2.2 3.4 2.7 GlxR*, AmtR
67 cg2137 aa gluB ABC-type glutamate transporter, substrate binding component 0 -1.38 -0.39 -0.6 2.7 1.3 2.4 3.3 3.5 4.9 5.5 5.1 GlxR*, AmtR
68 cg2138 aa gluC ABC-type glutamate transporter, permease component 6 -1.19 -0.33 - - - 1.8 1.3 3.0 - - -0.6 GlxR*, AmtR
69 cg2167   rpsO 30S ribosomal protein S15 0 -1.01 -0.14 1.1 1.8 1.9 -0.4 - - - -0.6 0.6  
70 cg2181    ABC-type peptide transporter, periplasmic component 0 -2.20 -0.53 -0.2 3.5 1.5 2.8 4.0 4.1 3.9 5.7 5.6 AmtR
71 cg2234    ABC-type cobalamin/Fe3+-siderophores transporter, secreted component 0 -1.32 n.d. -0.6 - - -0.4 0.7 - -0.9 -0.6 - DtxR, RamB*
72 cg2235   rplS 50S ribosomal protein L19 0 -1.40 -0.46 2.5 2.2 1.9 6.6 6.9 7.5 3.0 3.9 3.7  
73 cg2253   rpsP 30S ribosomal protein S16 0 -1.14 -0.34 4.1 4.7 4.0 1.2 1.3 2.5 1.6 -0.6 -0.4  
74 cg2467 ac   ABC-type peptide transporter, substrate binding component 0 -1.21 -0.17 - - - -0.4 2.8 2.8 1.4 -0.6 2.1  
75 cg2470 ac   ABC-type peptide transporter, substrate binding component 0 -1.66 -0.36 0.7 2.2 1.2 1.2 1.3 0.0 2.8 3.4 3.4  
76 cg2559 ad aceB Malate synthase G 0 -1.21 n.d. -0.6 4.7 2.0 - - - - - - RamA, RamB
77 cg2560 ad aceA Isocitrate lyase 0 -2.73 -2.19 - 4.9 2.4 - -0.3 - - - - RamA, RamB
78 cg2573   rpsT 30S ribosomal protein S20 0 -1.33 -0.56 2.8 3.3 2.1 2.7 2.7 3.5 1.6 1.4 1.2  
79 cg2603   ndk Nucleoside diphosphate kinase 0 -1.19 -0.20 2.8 3.3 3.2 - - - - - -  
80 cg2647   tig Trigger factor 0 -1.47 -0.27 4.8 5.4 5.0 - - - - - -  
81 cg2703    ABC-type transporter, permease component 6 -1.90 -0.32 - - - - - - - - -  
82 cg2705    ABC-type transporter, periplasmic component 0 -1.68 -0.28 4.9 7.0 5.8 6.9 7.7 8.0 6.8 7.6 7.4  
83 cg2840   actA Butyryl-CaA-acetate coenzyme A transferase 0 -1.67 -0.01 6.4 7.1 7.6 3.4 4.9 3.2 - 2.0 0.4 RamB*
84 cg2953   xylC Benzaldehyde dehydrogenase 0 -1.39 0.61 1.6 3.3 4.1 1.3 4.3 3.7 - - 1.5 GlxR*
85 cg3011   groL2 60 kDa chaperonin 2 (HSP60) 0 -2.20 -0.44 5.9 6.7 6.8 -0.4 1.7 3.5 2.2 2.4 3.0  
86 cg3048   pta Phosphate acetyltransferase 0 -1.07 0.16 - 1.7 2.3 - 2.9 2.8 - - - RipA, RamA, RamB
87 cg3096    NAD-dependent aldehyde dehydrogenases 0 -3.24 0.10 3.2 6.6 5.9 3.0 6.1 5.7 - 1.0 1.4  
88 cg3107   adhA Zn-dependent alcohol dehydrogenases 0 -1.97 0.06 - 2.9 1.8 - 5.6 4.9 - 3.7 -0.4 RamA, RamB, GlxR*
89 cg3156   htaA secreted protein implicated in iron acquisition and transport 0 -2.50 -2.76 - - - - - -0.3 2.7 5.7 - DtxR
90 cg3195    Flavin-containing monooxygenase 0 -2.23 0.32 - 2.2 -0.8 - 4.9 3.9 - 3.7 2.1  
91 cg3212    Hypothetical membrane protein 0 -1.92 -0.50 - - - - - - - - -  
  1. Genes for which an increased or decreased mRNA level was found at pH 6 in comparison to pH 7.5. The gene locus tag, organisation in operons, the gene name, the (proposed) function of the protein as well as the predicted number of transmembrane helices are given. The results of the transcriptome analysis are given as induction factor at pH 6 and pH 9 in comparison to pH 7.5. Results of the proteome analysis are indicated for the soluble, membrane and envelope fraction. Regulators of particular genes are given based on the CoryneRegNet data base. For further details see legend of Table 1.