Table 3 Differential metabolite pattern at pH 6 in comparison to pH 7.5
Metabolite | differential content | t-test |
|---|---|---|
Methionine synthesis | ||
homolanthionine | -15.28 | 0.0392 |
Serine | -1.84 | 0.0307 |
Glycine | -1.67 | 0.0010 |
homocysteine | -1.41 | 0.2019 |
methionine | -1.09 | 0.9449 |
threonine | 1.26 | 0.0302 |
Aspartate | 1.33 | 0.1295 |
homoserine | 1.58 | 0.3969 |
O-acetyl-serine | 2.34 | 0.0165 |
S-adenosyl-homocysteine | 2.45 | 0.0441 |
cysteine | 2.46 | 0.0030 |
O-acetyl-homoserine | 3.71 | 0.0002 |
cystathionine | 6.96 | 0.0044 |
Glycolysis and Pentosephosphate pathway | ||
Pep | -3.58 | 0.0025 |
DHAP | -2.89 | 0.0004 |
DHAP | -2.79 | 0.0010 |
glycerate-3-P | -1.99 | 0.0043 |
gluconate-6-P | -1.77 | 0.1733 |
ribose-5-P | -1.44 | 0.0373 |
fructose-1-6-P | 2.07 | 0.0360 |
glycerate-2-P | 2.86 | n.d. |
fructose-6-P | 3.00 | 0.0009 |
glucose-6-P | 3.18 | 0.0000 |
glucose-6-P | 3.85 | 0.0006 |
pyruvate | 11.10 | 0.0341 |
TCA cycle | ||
alpha-ketoglutarate | -6.07 | 0.0131 |
succinate | -5.37 | 0.0039 |
fumarate | 1.25 | 0.1755 |
citrate | 1.84 | 0.0775 |
malate | 2.06 | 0.0065 |
Amino acids | ||
proline | -8.67 | 0.0006 |
beta-alanine | -7.30 | 0.0000 |
ornithine, citrulline, arginine | -2.38 | 0.2871 |
serine | -1.84 | 0.0307 |
glycine | -1.67 | 0.0010 |
lysine | -1.58 | 0.3466 |
asparagine | -1.45 | 0.3712 |
methionine | -1.09 | 0.9449 |
leucine | 1.01 | 0.9353 |
glutamate | 1.02 | 0.7068 |
tyrosine | 1.17 | 0.1464 |
threonine | 1.26 | 0.0302 |
L-aspartate | 1.33 | 0.1295 |
tryptophan | 1.40 | 0.0606 |
isoleucine | 1.73 | 0.0007 |
histidine | 2.28 | 0.2898 |
cysteine | 2.46 | 0.0030 |
alanine | 3.28 | 0.0117 |
glutamine | 4.85 | 0.0002 |
valine | 5.52 | 0.0013 |
phenylalanine | 9.08 | 0.0020 |