Figure 1
From: Conservation of DNA-binding specificity and oligomerisation properties within the p53 family
Sedimentation profiles measured by fluorescence detection ultracentrifugation. A) Exemplary fitting of data (ΔNp63β, 50 nM, squares) to three normal distributions indicated by dashed (monomer), dotted (dimer) and dash-dotted lines (tetramer). The overall fit is indicated by the red line. B: Comparison of sedimentation traces for human p53 (triangles, green line), ΔNp63β (circles, red line) and ΔNp73β (squares, black line) at a concentration of 50 nM (monomer). Intensities are normalised to the total integrated area.