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Figure 4 | BMC Genomics

Figure 4

From: Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

Figure 4

DNA-binding specificity of p53 family members. ΔlogKd plot for all competitor DNA sequences. Affinity penalties with respect to the reference sequence caused by base pair substitutions are shown for all nucleotides (A = black, T = green, G = red, C = blue). The reference sequence is indicated below the axis. Only the analysed half-site is shown. A positive value indicates weaker binding of the competitor sequence than the reference sequence, whereas a negative value indicates that the substitution leads to tighter protein-DNA binding.

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