Figure 7
From: Conservation of DNA-binding specificity and oligomerisation properties within the p53 family
The tetramerisation domain of human p53 and p73. A) Superposition of the crystal structures of the tetramerisation domain of human p53 (green) [57] and human p73 (purple) [25], showing that p73 contains an additional C-terminal helix. This helix is conserved in the p63 sister protein. B) Primary-dimer interface of human p53. The side chains of Y327, L330, I332, R333, F338, L344 (green) and the salt bridge between R337 and D352 (orange) are shown as stick models. The salt bridge is not conserved in human p63 and p73.