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Table 5 GO categories and KEGG pathways overrepresented among differentially expressed genes (P ≤ 0.05) four hours post-exercise compared to pre-exercise levels.

From: Transcriptional adaptations following exercise in Thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy

GO ID

Molecular Function

GO Term

No. Genes

P

Fold Enrichment

GO:0005515

protein binding

352

0.004

1.09

GO:0016853

isomerase activity

19

0.007

1.85

GO:0005200

structural constituent of cytoskeleton

7

0.026

2.72

GO:0003700

transcription factor activity

39

0.031

1.36

GO:0016860

intramolecular oxidoreductase activity

8

0.037

2.33

GO:0031072

heat shock protein binding

9

0.078

1.91

GO:0051082

unfolded protein binding

16

0.096

1.49

Cellular Compartment

    

GO:0044428

nuclear part

83

0.009

1.27

GO:0044446

intracellular organelle part

194

0.015

1.13

GO:0044422

organelle part

195

0.016

1.13

GO:0031974

membrane-enclosed lumen

75

0.018

1.26

GO:0043233

organelle lumen

75

0.018

1.26

GO:0005667

transcription factor complex

19

0.024

1.67

GO:0015629

actin cytoskeleton

15

0.029

1.78

GO:0044451

nucleoplasm part

37

0.032

1.37

GO:0005886

plasma membrane

79

0.042

1.20

GO:0016020

membrane

222

0.049

1.09

GO:0005654

nucleoplasm

40

0.061

1.29

GO:0031981

nuclear lumen

51

0.064

1.24

GO:0001725

stress fiber

4

0.066

3.79

GO:0032432

actin filament bundle

4

0.066

3.79

GO:0030864

cortical actin cytoskeleton

4

0.066

3.79

GO:0030863

cortical cytoskeleton

5

0.066

2.96

GO:0030054

cell junction

15

0.074

1.58

GO:0044433

cytoplasmic vesicle part

10

0.077

1.82

GO:0030659

cytoplasmic vesicle membrane

10

0.077

1.82

GO:0044448

cell cortex part

6

0.087

2.37

GO:0031410

cytoplasmic vesicle

28

0.090

1.33

GO:0012506

vesicle membrane

10

0.095

1.75

GO:0016023

cytoplasmic membrane-bound vesicle

24

0.098

1.35

GO:0005770

late endosome

7

0.100

2.07

Biological Process

    

GO:0051640

organelle localization

5

0.021

3.92

GO:0006457

protein folding

29

0.029

1.45

GO:0051650

establishment of vesicle localization

4

0.032

4.70

GO:0051648

vesicle localization

4

0.032

4.70

GO:0006903

vesicle targeting

4

0.032

4.70

GO:0050790

regulation of catalytic activity

26

0.044

1.44

GO:0051726

regulation of cell cycle

34

0.045

1.36

GO:0000074

regulation of progression through cell cycle

34

0.045

1.36

GO:0048523

negative regulation of cellular process

64

0.050

1.22

GO:0016568

chromatin modification

19

0.058

1.51

GO:0051656

establishment of organelle localization

4

0.067

3.76

GO:0065009

regulation of a molecular function

29

0.076

1.34

GO:0048519

negative regulation of biological process

65

0.080

1.19

GO:0007049

cell cycle

49

0.080

1.23

GO:0031324

negative regulation of cellular metabolic process

25

0.082

1.37

KEGG ID

    

hsa04010

MAPK signaling pathway

13

0.060

1.69

hsa04510

Focal adhesion

17

0.099

1.45

hsa04115

p53 signaling pathway

5

0.163

2.24

hsa00590

Arachidonic acid metabolism

3

0.182

3.70

hsa04910

Insulin signaling pathway

9

0.183

1.59

hsa05211

Renal cell carcinoma

7

0.198

1.73

hsa04670

Leukocyte transendothelial migration

7

0.233

1.64

hsa04150

mTOR signaling pathway

4

0.265

2.19

hsa00720

Reductive carboxylate cycle (CO2 fixation)

3

0.265

2.96

hsa04930

Type II diabetes mellitus

3

0.265

2.96

  1. The FatiScan gene enrichment test was used to analyse the data