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Table 6 β-lactam resistance genes pbp1a (penicillin), pbp2b (amoxicillin), and pbp2x (ceftriaxone) from reference strain R6 (Genbank AE007317), representative CBSN isolates, US isolates, and South Korean isolates.

From: Genome-wide dissection of globally emergent multi-drug resistant serotype 19A Streptococcus pneumoniae

  Changes in amino acids of conserved PBP sites
  pbp 1a pbp 2x pbp 2b
Strain 370-373 428-432 557-559 337-340 394-397 400-401 546-549 385-388 442-445 614-616
19F-14 SAMK   KTG SAMK HSSN MS     
MOH55 SSMK SRNVT KTG SAMK HSSN MS VKSG SVVK SSNA KTGTG
MOH56 SSMK SRNVT KTG SAMK HSSN MS VKSG SVVK SSNA KTGTG
MOH147 STMK SRNVP KTG SAMK HSSN MT LKSG SVVK SSNA KTGTA
MOH83 SSMK SRNVT KTG SAMK HSSN MS VKSG SVVK SSNA KTGTG
MOH62 SSMK SRNVT KTG SAMK HSSN MS VKSG SVVK SSNA KTGTG
Kor914 SSMK SRNVT KTG SAMK HSSN MS VKSG SVVK SSNA KTGTG
Kor21 SSMK SRNVT KTG SAMK HSSN MS VKSG SVVK SSNA KTGTG
Kor39 SSMK SRNVT KTG SAMK HSSN MS VKSG SVVK SSNA KTGTG
PU1175 SSMK SRNVT KTG SAMK HSSN MS VKSG SVVK SSNA KTGTG
PU6055 SSMK SRNVT KTG SAFK HSSN TS VKSG SVVK SSNA KTGTG
  1. Serotype (SERO), sequence type (ST), clonal complex (CC) and MIC values (mg/mL) for penicillin (PEN), ceftriaxone (CTX) and amoxicillin (AMOX) are indicated. Residues associated with resistance to β lactams are in bold letters. Ceftriaxone MIC values for South Korea isolates were unavailable. Of note, Taiwan 19F-14 (ST236) [Genbank E043521/E043522] retains residues similar to 19F and 19A in this study at certain residues of pbp1a and pbp2x. For the complete data set, including Tn2010-related resistance genes, see Additional file 3.