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Figure 6 | BMC Genomics

Figure 6

From: Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice

Figure 6

Alzheimer disease genes in female and male double-transgenic mice. Differentially expressed genes of female and male ADAM10/APP[V717I] versus APP[V717I] and of dnADAM10/APP[V717I]versus APP[V717I] with FDR 1.3, restricted to the 600 best up- and downregulated genes were analyzed for AD genes (934 genes) from GeneCards (Weizmann Institute of Science, Version 2.36). In female ADAM10/APP[V717I] versus APP[V717I] mice 49 AD genes (8% of 600 genes) and in female dnADAM10/APP[V717I] versus APP[V717I] animals 35 AD genes (6% of 600 genes) were found to be affected. In male ADAM10/APP[V717I] versus APP[V717I] mice 42 AD genes (7% of 600 genes) and in male dnADAM10/APP[V717I] versus APP[V717I] mice 31 AD genes (5% of 600 genes) were found to be affected. The corresponding d-values are listed separately for male (Tab. 9) and female mice (Tab. 10).

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