Table 4 Significantly regulated genes in mono-transgenic ADAM10 mice in relation to FVB/N wild-type mice
From: Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
Gene ID | Gene symbol | Description | Fold change | log ratio | d-value | Functional groups |
|---|---|---|---|---|---|---|
27360 | Add3 | adducin 3 (gamma) | 1.519 | 0.603 | 2.841 | receptor binding and activity |
68465 | Adipor2 | adiponectin receptor 2 | 1.365 | 0.449 | 2.294 | cell communication |
11658 | Alcam | activated leukocyte cell adhesion molecule | 1.471 | 0.557 | 2.298 | nervous system development; neuron projection |
211673 | Arfgef1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) | 1.503 | 0.588 | 2.644 | cell communication |
11855 | Arhgap5 | Rho GTPase activating protein 5 | 1.621 | 0.697 | 2.526 | cell communication |
98660 | Atp1a2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.792 | -0.337 | -1.972 | cell communication; synapse |
11941 | Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | 1.734 | 0.794 | 2.717 | cell communication; nervous system development; receptor binding and activity; synapse |
22589 | Atrx | alpha thalassemia/mental retardation syndrome X-linked homolog (human) | 1.507 | 0.592 | 2.876 | nervous system development |
30948 | Bin1 | bridging integrator 1 | 1.451 | 0.537 | 2.318 | cell communication; synapse |
12298 | Cacnb4 | calcium channel, voltage-dependent, beta 4 subunit | 1.800 | 0.848 | 2.913 | cell communication; synapse |
12322 | Camk2a | calcium/calmodulin-dependent protein kinase II alpha | 1.779 | 0.831 | 2.547 | cell communication; receptor binding and activity; synapse |
16149 | Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | 0.724 | -0.466 | -2.270 | cell communication; cell death |
212285 | Centd1 | centaurin, delta 1 | 1.569 | 0.650 | 2.530 | cell communication |
12633 | Cflar | CASP8 and FADD-like apoptosis regulator | 1.393 | 0.478 | 2.497 | cell death |
12704 | Cit | citron | 1.476 | 0.562 | 2.405 | cell communication; nervous system development |
12803 | Cntf | ciliary neurotrophic factor | 1.496 | 0.581 | 2.355 | cell communication; nervous system development |
70086 | Cysltr2 | cysteinyl leukotriene receptor 2 | 1.307 | 0.386 | 2.251 | cell communication |
13618 | Ednrb | endothelin receptor type B | 1.364 | 0.448 | 2.506 | cell communication; nervous system development |
13838 | Epha4 | Eph receptor A4 | 1.622 | 0.698 | 2.439 | cell communication; nervous system development |
67456 | Ergic2 | ERGIC and golgi 2 | 1.367 | 0.451 | 2.316 | cell communication; synapse |
14397 | Gabra4 | gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4 | 1.542 | 0.625 | 2.316 | cell communication; synapse |
14417 | Gad2 | glutamic acid decarboxylase 2 | 1.636 | 0.710 | 3.290 | cell communication; neuron projection; synapse |
14674 | Gna13 | guanine nucleotide binding protein, alpha 13 | 1.502 | 0.587 | 2.257 | cell communication |
14677 | Gnai1 | guanine nucleotide binding protein, alpha inhibiting 1 | 1.576 | 0.656 | 2.911 | cell communication |
14680 | Gnal | guanine nucleotide binding protein, alpha stimulating, olfactory type | 1.598 | 0.676 | 3.061 | cell communication |
53623 | Gria3 | glutamate receptor, ionotropic, AMPA3 (alpha 3) | 1.480 | 0.566 | 2.388 | synapse |
56637 | Gsk3b | glycogen synthase kinase 3 beta | 1.540 | 0.623 | 2.382 | cell communication; cell death |
15208 | Hes5 | hairy and enhancer of split 5 (Drosophila) | 0.749 | -0.416 | -1.800 | nervous system development |
16419 | Itgb5 | integrin beta 5 | 0.786 | -0.347 | -2.185 | cell adhesion; cell communication |
16510 | Kcnh1 | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 1.398 | 0.483 | 2.291 | cell communication; receptor binding and activity |
16561 | Kif1b | kinesin family member 1B | 1.555 | 0.637 | 2.573 | cell communication; synapse |
16573 | Kif5b | kinesin family member 5B | 1.904 | 0.929 | 3.186 | neuron projection; synapse |
16574 | Kif5c | kinesin family member 5C | 1.656 | 0.728 | 2.463 | nervous system development; neuron projection; synapse |
110829 | Lims1 | LIM and senescent cell antigen-like domains 1 | 1.533 | 0.616 | 2.309 | cell adhesion |
108030 | Lin7a | lin-7 homolog A (C. elegans) | 1.346 | 0.429 | 2.260 | cell communication; synapse |
319387 | Lphn3 | latrophilin 3 | 1.295 | 0.373 | 2.344 | cell communication |
16971 | Lrp1 | low density lipoprotein receptor-related protein 1 | 0.707 | -0.500 | -2.139 | cell communication |
16998 | Ltbp3 | latent transforming growth factor beta binding protein 3 | 0.791 | -0.338 | -2.180 | cell communication; receptor binding and activity |
50791 | Magi2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 1.426 | 0.512 | 2.399 | cell communication |
192167 | Nlgn1 | neuroligin 1 | 1.518 | 0.602 | 2.386 | cell communication; nervous system development; synapse |
18549 | Pcsk2 | proprotein convertase subtilisin/kexin type 2 | 1.492 | 0.577 | 2.393 | nervous system development |
18573 | Pde1a | phosphodiesterase 1A, calmodulin-dependent | 1.796 | 0.845 | 3.130 | cell communication; receptor binding and activity |
18596 | Pdgfrb | platelet derived growth factor receptor, beta polypeptide | 0.800 | -0.322 | -1.867 | cell communication |
18613 | Pecam1 | platelet/endothelial cell adhesion molecule 1 | 0.778 | -0.363 | -2.093 | cell communication |
18795 | Plcb1 | phospholipase C, beta 1 | 1.652 | 0.724 | 3.345 | cell communication |
18798 | Plcb4 | phospholipase C, beta 4 | 1.480 | 0.566 | 2.451 | cell communication |
242083 | Ppm1l | protein phosphatase 1 (formerly 2C)-like | 1.604 | 0.682 | 2.277 | cell communication |
26932 | Ppp2r5e | protein phosphatase 2, regulatory subunit B (B56), epsilon isoform | 1.578 | 0.658 | 2.298 | cell communication |
19281 | Ptprt | protein tyrosine phosphatase, receptor type, T | 1.409 | 0.495 | 2.354 | cell communication |
19328 | Rab12 | RAB12, member RAS oncogene family | 1.250 | 0.322 | 2.259 | cell communication |
270192 | Rab6b | RAB6B, member RAS oncogene family | 1.696 | 0.762 | 2.837 | cell communication; synapse |
56044 | Rala | v-ral simian leukemia viral oncogene homolog A (ras related) | 1.582 | 0.662 | 2.544 | cell communication |
54409 | Ramp2 | receptor (calcitonin) activity modifying protein 2 | 1.693 | 0.760 | 2.640 | cell communication |
218397 | Rasa1 | RAS p21 protein activator 1 | 1.428 | 0.514 | 2.266 | cell adhesion; cell communication; cell death |
19737 | Rgs5 | regulator of G-protein signaling 5 | 1.677 | 0.746 | 2.390 | cell communication |
19894 | Rph3a | rabphilin 3A | 1.470 | 0.556 | 2.352 | synapse |
68585 | Rtn4 | reticulon 4 | 1.542 | 0.625 | 2.344 | cell death; nervous system development |
20202 | S100a9 | S100 calcium binding protein A9 | 0.668 | -0.582 | -2.146 | cell communication |
20377 | Sfrp1 | secreted frizzled-related sequence protein 1 | 0.793 | -0.335 | -1.730 | cell communication |
239250 | Slitrk6 | SLIT and NTRK-like family, member 6 | 1.324 | 0.405 | 2.293 | nervous system development |
93761 | Smarca1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 1.309 | 0.388 | 2.351 | nervous system development |
66042 | Sostdc1 | sclerostin domain containing 1 | 0.725 | -0.464 | -1.768 | cell communication |
20742 | Spnb2 | spectrin beta 2 | 1.729 | 0.790 | 2.855 | cell communication; receptor binding and activity |
114716 | Spred2 | sprouty-related, EVH1 domain containing 2 | 1.514 | 0.598 | 2.653 | cell communication |
21961 | Tns1 | tensin 1 | 1.505 | 0.590 | 2.245 | cell communication |
22370 | Vtn | vitronectin | 0.778 | -0.362 | -1.925 | cell adhesion |
22371 | Vwf | Von Willebrand factor homolog | 0.715 | -0.484 | -2.099 | cell adhesion |
57750 | Wdr12 | WD repeat domain 12 | 1.391 | 0.476 | 2.446 | cell communication |
232341 | Wnk1 | WNK lysine deficient protein kinase 1 | 1.844 | 0.883 | 2.947 | cell communication |
22772 | Zic2 | Zinc finger protein of the cerebellum 2 | 1.941 | 0.957 | 3.062 | nervous system development |