Table 7 Significantly regulated genes in double-transgenic dnADAM10/APP[V717I] mice in relation to mono-transgenic APP[V717I] mice
From: Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
Gene ID | Gene symbol | Description | Fold change | log ratio | d-value | Functional groups |
|---|---|---|---|---|---|---|
268860 | Abat | 4-aminobutyrate aminotransferase | 1.503 | 0.588 | 3.791 | cell communication; synapse |
67269 | Agtpbp1 | ATP/GTP binding protein 1 | 1.397 | 0.482 | 3.311 | cell communication; synapse |
226548 | Aph1a | anterior pharynx defective 1a homolog (C. elegans) | 0.724 | -0.466 | -3.127 | cell communication |
11938 | Atp2a2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 1.456 | 0.542 | 3.900 | cell communication |
140494 | Atp6v0a4 | ATPase, H+ transporting, lysosomal V0 subunit A4 | 0.762 | -0.392 | -2.972 | cell communication |
12122 | Bid | BH3 interacting domain death agonist | 1.381 | 0.466 | 3.765 | cell death |
12293 | Cacna2d1 | calcium channel, voltage-dependent, alpha2/delta subunit 1 | 1.460 | 0.546 | 4.086 | cell communication |
20303 | Ccl4 | chemokine (C-C motif) ligand 4 | 0.755 | -0.405 | -2.995 | receptor binding and activity |
12772 | Ccr2 | chemokine (C-C motif) receptor 2 | 0.648 | -0.625 | -3.824 | cell communication |
12955 | Cryab | crystallin, alpha B | 0.711 | -0.492 | -3.095 | cell communication |
12977 | Csf1 | colony stimulating factor 1 (macrophage) | 0.767 | -0.383 | -2.920 | cell adhesion; cell communication; receptor binding and activity |
56066 | Cxcl11 | chemokine (C-X-C motif) ligand 11 | 0.760 | -0.395 | -2.953 | receptor binding and activity |
20315 | Cxcl12 | chemokine (C-X-C motif) ligand 12 | 1.373 | 0.457 | 3.359 | receptor binding and activity |
224997 | Dlgap1 | discs, large (Drosophila) homolog-associated protein 1 | 1.417 | 0.503 | 3.720 | cell communication; synapse |
13527 | Dtna | dystrobrevin alpha | 1.338 | 0.42 | 3.294 | synapse |
23882 | Gadd45g | growth arrest and DNA-damage-inducible 45 gamma | 1.371 | 0.455 | 3.534 | cell death |
14943 | Gzmf | granzyme F | 0.745 | -0.424 | -3.031 | cell death |
215114 | Hip1 | huntingtin interacting protein 1 | 0.772 | -0.373 | -2.971 | cell death |
15257 | Hipk1 | homeodomain interacting protein kinase 1 | 0.726 | -0.461 | -3.122 | cell death |
15452 | Hprt1 | hypoxanthine guanine phosphoribosyl transferase 1 | 1.375 | 0.459 | 3.326 | cell communication; cell death; synapse |
215257 | Il1f9 | interleukin 1 family, member 9 | 0.706 | -0.503 | -3.808 | receptor binding and activity |
16323 | Inhba | inhibin beta-A | 0.744 | -0.426 | -2.892 | cell death; receptor binding and activity |
16325 | Inhbc | inhibin beta-C | 0.715 | -0.483 | -3.508 | receptor binding and activity |
16179 | Irak1 | interleukin-1 receptor-associated kinase 1 | 1.431 | 0.517 | 3.661 | receptor binding and activity |
80782 | Klrb1d | killer cell lectin-like receptor subfamily B member 1D | 0.735 | -0.444 | -3.340 | cell death |
16818 | Lck | lymphocyte protein tyrosine kinase | 0.698 | -0.519 | -3.204 | cell communication; cell death |
17248 | Mdm4 | transformed mouse 3T3 cell double minute 4 | 1.377 | 0.462 | 3.303 | cell death |
59030 | Mkks | McKusick-Kaufman syndrome protein | 0.723 | -0.468 | -3.503 | cell communication |
17910 | Myo15 | myosin XV | 0.753 | -0.41 | -2.883 | cell communication |
18125 | Nos1 | nitric oxide synthase 1, neuronal | 0.741 | -0.432 | -3.040 | cell communication; receptor binding and activity; synapse |
21907 | Nr2e1 | nuclear receptor subfamily 2, group E, member 1 | 0.702 | -0.511 | -3.426 | cell communication; cell death |
57270 | Olfr1508 | olfactory receptor 1508 | 0.735 | -0.444 | -3.162 | cell communication |
18378 | Omp | olfactory marker protein | 0.756 | -0.403 | -2.860 | cell communication |
170677 | Pcdh21 | protocadherin 21 | 0.614 | -0.703 | -3.902 | cell communication |
14827 | Pdia3 | protein disulfide isomerase associated 3 | 0.745 | -0.424 | -2.866 | cell death |
18821 | Pln | phospholamban | 0.741 | -0.432 | -3.181 | cell communication |
333654 | Ppp1r13l | protein phosphatase 1, regulatory (inhibitor) subunit 13 like | 0.733 | -0.449 | -3.361 | cell death |
54189 | Rabep1 | rabaptin, RAB GTPase binding effector protein 1 | 1.377 | 0.462 | 3.307 | cell death; receptor binding and activity |
17252 | Rdh11 | retinol dehydrogenase 11 | 1.374 | 0.458 | 3.317 | cell communication |
212541 | Rho | rhodopsin | 0.762 | -0.393 | -3.078 | cell communication |
19877 | Rock1 | Rho-associated coiled-coil containing protein kinase 1 | 1.402 | 0.487 | 3.841 | cell death |
19893 | Rpgr | retinitis pigmentosa GTPase regulator | 1.361 | 0.445 | 3.332 | cell communication |
110876 | Scn2a1 | sodium channel, voltage-gated, type II, alpha 1 | 1.393 | 0.478 | 3.500 | cell communication; cell death |
58234 | Shank3 | SH3/ankyrin domain gene 3 | 0.769 | -0.379 | -2.946 | cell communication; cell death |
22293 | Slc45a2 | solute carrier family 45, member 2 | 0.731 | -0.453 | -3.211 | cell communication |
20682 | Sox9 | SRY-box containing gene 9 | 0.754 | -0.408 | -3.089 | cell death |
20977 | Syp | synaptophysin | 1.448 | 0.534 | 3.608 | cell communication; synapse |
20979 | Syt1 | synaptotagmin I | 1.397 | 0.482 | 3.587 | cell communication; synapse |
21823 | Th | tyrosine hydroxylase | 0.761 | -0.394 | -2.993 | cell communication; synapse |
94090 | Trim9 | tripartite motif protein 9 | 0.716 | -0.481 | -2.963 | cell communication; synapse |
59025 | Usp14 | ubiquitin specific peptidase 14 | 1.383 | 0.468 | 3.342 | cell communication; synapse |
16963 | Xcl1 | chemokine (C motif) ligand 1 | 0.749 | -0.416 | -3.003 | receptor binding and activity |