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Table 6 Comparison of commonly regulated gene families in PACAP-stimulated sympathetic primary neurons versus IL-induced PC12 cells (data derived from [53])

From: Expression profiling and Ingenuity biological function analyses of interleukin-6- versus nerve growth factor-stimulated PC12 cells

PACAP-stimulated sympathetic neurons (data are from[53])

  

IL-6-stimulated PC12 cells

Gene family

    

Gene abbreviation

9 hours

96 hours

Gene abbreviation

24 hours

Pituitary adenylate cyclase activating polypeptide

    

ADCYAP1

+

+

ADCYAP1

+

BCL2-like protein

    

BCL2L11

+

n.c.

BCL2L11

+

Chemokine Ligands

    

CXCL1

+

+

  
   

CXCL10

+

   

CXCL13

+

Cytochrome P450 proteins

    

CYP1B1

+

+

  
   

CYP4F16

+

Early growth response

    

EGR1

+

n.c.

EGR1

+

Glutathione S-transferase

    

GSTA3

+

n.c.

GSTA3

-

Heat shock proteins

    

HSP27B1

+

n.c.

HSP90B1

+

Janus kinase

    

JAK2

 

+

JAK2

+

Kruppel-like factors

    

KLF4

+

n.c.

KLF6

+

KLF9

+

n.c.

  

Nuclear factors

    

NFIA

+

n.c.

NFIB

+

Nuclear receptors

    

NR4A3

+

n.c.

  

NR4A2

+

n.c.

  

NR4A1

+

n.c.

  
   

NR3C2

+

Sialytransferases

    

ST8SIA1

+

+

ST8SIA3

-

ST6GAL1

+

+

ST6GAL1

+

Solute carrier proteins

    

SLC1A3

+

n.c.

  

SLC2A1

 

+

  

SLC2A3

+

+

  
   

SLC6A3

+

SLC7A1

+

+

  

SLC7A3

 

+

  
   

SLC12A5

-

SLC18A2

+

+

  
   

SLC30A2

-

SLC24A2

 

+

  

Tubulins

    

TUBA1

-

n.c.

  
   

TUBB

+

Tissue Inhibitor of metalloproteinase

    

TIMP1

+

+

TIMP1

+

  1. +, upregulated -, downregulated; n.c., not changed from control cultures; gene symbols are from IPA Tool