Figure 2

Comparison of substitution rates for genome-wide miRNAs between human and mouse by chromosomes. Substitution rate differences of genome-wide mature miRNAs and precursor miRNAs between the X chromosome and autosomes are shown. Substitution rates were calculated from orthologous sequences of human and mouse using the Kimura 2-parameter model. All comparisons showed significant differences (**, p < 0.01).