Protein disorder in the human diseasome: unfoldomics of human genetic diseases

BMC Genomics

Table 1 Disease class names and acronyms, number of diseases and number of genes related to disease classes.

Class name	Acronym	Number of diseases	% (of 1284)	Number of genes	% (of 1751)
Skeletal	SKEL	64	4.98%	56	3.20%
Bone	BONE	30	2.34%	44	2.51%
Dermatological	DERM	48	3.74%	80	4.57%
Cancer	CANC	113	8.80%	207	11.82%
Developmental	DEVE	37	2.88%	53	3.03%
Multi-class disease	MCD	155	12.07%	209	11.94%
Cardiovascular	CARD	41	3.19%	96	5.48%
Muscular	MUSC	31	2.41%	68	3.88%
Immunological	IMMU	69	5.37%	115	6.57%
Ophthamological	OPHT	62	4.83%	120	6.85%
Connective tissue disorder	CTD	28	2.18%	51	2.91%
Endocrine	ENDO	56	4.36%	96	5.48%
Neurological	NEUR	117	9.11%	254	14.51%
Psychiatric	PSYC	17	1.32%	30	1.71%
Ear, Nose, Throat	ENT	6	0.47%	44	2.51%
Respiratory	RESP	13	1.01%	34	1.94%
Renal	RENA	36	2.80%	58	3.31%
Hematological	HEMA	88	6.85%	146	8.34%
Nutritional	NUTR	4	0.31%	22	1.26%
Gastrointestinal	GI	23	1.79%	34	1.94%
Unclassified	UNCL	31	2.41%	29	1.66%
Metabolic	META	215	16.74%	289	16.50%
Multiple class genes	MULT			295	16.85%
Disease genes	DIS			1751	100.00%
Human genes	HUM			18109

The same order of classes is used in graphs in the Results section; the first 22 classes are sorted in descending order with respect to the median of disorder content (defined in Experimental procedures). The difference between "multi-class diseases" and "multiple class genes" is that "multi-class diseases" set includes genes that are only related to diseases that are classified as "multiple" in [47], whereas "multiple class genes" includes genes that are related to several diseases that belong to different classes.

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