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Table 1 Disease class names and acronyms, number of diseases and number of genes related to disease classes.

From: Protein disorder in the human diseasome: unfoldomics of human genetic diseases

Class name Acronym Number of diseases %
(of 1284)
Number of genes %
(of 1751)
Skeletal SKEL 64 4.98% 56 3.20%
Bone BONE 30 2.34% 44 2.51%
Dermatological DERM 48 3.74% 80 4.57%
Cancer CANC 113 8.80% 207 11.82%
Developmental DEVE 37 2.88% 53 3.03%
Multi-class disease MCD 155 12.07% 209 11.94%
Cardiovascular CARD 41 3.19% 96 5.48%
Muscular MUSC 31 2.41% 68 3.88%
Immunological IMMU 69 5.37% 115 6.57%
Ophthamological OPHT 62 4.83% 120 6.85%
Connective tissue disorder CTD 28 2.18% 51 2.91%
Endocrine ENDO 56 4.36% 96 5.48%
Neurological NEUR 117 9.11% 254 14.51%
Psychiatric PSYC 17 1.32% 30 1.71%
Ear, Nose, Throat ENT 6 0.47% 44 2.51%
Respiratory RESP 13 1.01% 34 1.94%
Renal RENA 36 2.80% 58 3.31%
Hematological HEMA 88 6.85% 146 8.34%
Nutritional NUTR 4 0.31% 22 1.26%
Gastrointestinal GI 23 1.79% 34 1.94%
Unclassified UNCL 31 2.41% 29 1.66%
Metabolic META 215 16.74% 289 16.50%
Multiple class genes MULT    295 16.85%
Disease genes DIS    1751 100.00%
Human genes HUM    18109  
  1. The same order of classes is used in graphs in the Results section; the first 22 classes are sorted in descending order with respect to the median of disorder content (defined in Experimental procedures). The difference between "multi-class diseases" and "multiple class genes" is that "multi-class diseases" set includes genes that are only related to diseases that are classified as "multiple" in [47], whereas "multiple class genes" includes genes that are related to several diseases that belong to different classes.