Number of proteins targeted in signal transduction pathways by HIV-1. This graph represents the mapping of the NCI PID  and Reactome  databases with respect to HIV-1 targets obtained from the NIAID database  and predicted through information integration . The pathways are sorted by the number of proteins known to interact with HIV-1 per pathway, referred to as Group 1 targets (for details, see Methods). The data is compared to other definitions of HIV-1, human protein pairs: Group 2 targets (more likely functional interactions from the NIAID database), predicted targets , Expert validated targets 1 (where any expert annotated group 1 targets), Expert validated targets 2 (where all of the experts annotated Group 1 targets with the same label, i.e. they all agreed that the interaction is real). We also plot the total number of proteins in the pathway for comparison. Highlighted are the pathways that are discussed in this paper, with reference to their rank according to the number of Group 1 targets, and the Figure in which they are illustrated.