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Table 2 Proteins in generation of the second messenger molecules pathway. This table lists the proteins that are the constituents of the generation of the second messengers pathway (Figure 3 and 4). Column 1 gives the uniprot identifier, column 2 the short gene description, column 3 the gene symbol and column 4 highlights the features of this protein, including whether or not it is a HIV-1, siRNA or drug target.

From: Alternative paths in HIV-1 targeted human signal transduction pathways

Uniprot id Gene description Gene Symbol Properties
P07766 CD3e molecule epsilon (CD3-TCR complex) CD3E HIV-1 target according to Group 1, Group 2 and predictions, known drug target
Q13094 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) LCP2 HIV-1 target according to predictions, siRNA protein
P04234 CD3d molecule delta (CD3-TCR complex) CD3D HIV-1 target according to Group 1, Group 2 and predictions
P19174 phospholipase C gamma 1 PLCG1 HIV-1 target according to Group 2, and predictions
O43561 linker for activation of T cells LAT None
O75791 GRB2-related adaptor protein 2 GRAP2 None
P01730 CD4 molecule CD4 HIV-1 target according to Group 1, Group 2, predictions, and experts, siRNA protein
P09693 CD3g molecule gamma (CD3-TCR complex) CD3G HIV-1 target according to Group 1, Group 2, and predictions
P43403 zeta-chain (TCR) associated protein kinase 70kDa ZAP70 HIV-1 target according to Group 1, Group 2, and predictions, known drug target
Q08881 IL2-inducible T-cell kinase ITK Known drug target
P06239 lymphocyte-specific protein tyrosine kinase LCK HIV-1 target according to Group 1, Group 2, and predictions
P20963 CD247 molecule CD247 HIV-1 target according to Group 1, predictions and experts