Table 3 Proteins in EGFR downregulation pathway. This table lists the proteins that are the constituents of the EGFR downregulation pathway (Figure 5D). Column 1 gives the uniprot identifier, column 2 the short gene description, column 3 the gene symbol and column 4 highlights the features of this protein, including whether or not it is a HIV-1, siRNA or drug target.
From: Alternative paths in HIV-1 targeted human signal transduction pathways
Uniprot id | Gene description | Gene Symbol | Properties |
|---|---|---|---|
O94973 | adaptor-related protein complex 2 alpha 2 subunit | AP2A2 | HIV-1 target according to Group1, predictions and the experts |
Q96B97 | SH3-domain kinase binding protein 1 | SH3KBP1 | HIV-1 target according to predictions |
P09496 | clathrin light chain (Lca) | CLTA | siRNA protein |
P22681 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | CBL | HIV-1 target according to Group 2 and predictions |
Q9UBC2 | epidermal growth factor receptor pathway substrate 15-like 1 | EPS15L1 | None |
P01133 | epidermal growth factor (beta-urogastrone) | EGF | HIV-1 target according to Group 1 and predictions, siRNA protein and known drug target |
P62993 | growth factor receptor-bound protein 2 | GRB2 | HIV-1 target according to Group 2 and predictions, known drug target |
Q00610 | clathrin heavy chain (Hc) | CLTC | HIV-1 target according to Group 1 and predictions |
Q9Y6I3 | epsin 1 | EPN1 | None |
O95782 | adaptor-related protein complex 2 alpha 1 subunit | AP2A1 | HIV-1 target according to Group 1, predictions and experts |
Q99962 | SH3-domain GRB2-like 2 | SH3GL2 | None |
P42566 | epidermal growth factor receptor pathway substrate 15 | EPS15 | HIV-1 target according to predictions |
P00533 | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog avian) | EGFR | HIV-1 target according to Group 2, and predictions, siRNA protein and known drug target |
O14964 | hepatocyte growth factor-regulated tyrosine kinase substrate | HGS | HIV-1 target according to Group 2, siRNA protein |
P60953 | cell division cycle 42 (GTP binding protein 25 kDa) | CDC42 | HIV-1 target according to Group 1 and predictions |
P62988 | ribosomal protein S27a | RPS27A | HIV-1 target according to Group 1, predications and experts, known drug target |
O43597 | sprouty homolog 2 (Drosophila) | SPRY2 | None |