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Table 3 Proteins in EGFR downregulation pathway. This table lists the proteins that are the constituents of the EGFR downregulation pathway (Figure 5D). Column 1 gives the uniprot identifier, column 2 the short gene description, column 3 the gene symbol and column 4 highlights the features of this protein, including whether or not it is a HIV-1, siRNA or drug target.

From: Alternative paths in HIV-1 targeted human signal transduction pathways

Uniprot id Gene description Gene Symbol Properties
O94973 adaptor-related protein complex 2 alpha 2 subunit AP2A2 HIV-1 target according to Group1, predictions and the experts
Q96B97 SH3-domain kinase binding protein 1 SH3KBP1 HIV-1 target according to predictions
P09496 clathrin light chain (Lca) CLTA siRNA protein
P22681 Cas-Br-M (murine) ecotropic retroviral transforming sequence CBL HIV-1 target according to Group 2 and predictions
Q9UBC2 epidermal growth factor receptor pathway substrate 15-like 1 EPS15L1 None
P01133 epidermal growth factor (beta-urogastrone) EGF HIV-1 target according to Group 1 and predictions, siRNA protein and known drug target
P62993 growth factor receptor-bound protein 2 GRB2 HIV-1 target according to Group 2 and predictions, known drug target
Q00610 clathrin heavy chain (Hc) CLTC HIV-1 target according to Group 1 and predictions
Q9Y6I3 epsin 1 EPN1 None
O95782 adaptor-related protein complex 2 alpha 1 subunit AP2A1 HIV-1 target according to Group 1, predictions and experts
Q99962 SH3-domain GRB2-like 2 SH3GL2 None
P42566 epidermal growth factor receptor pathway substrate 15 EPS15 HIV-1 target according to predictions
P00533 epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog avian) EGFR HIV-1 target according to Group 2, and predictions, siRNA protein and known drug target
O14964 hepatocyte growth factor-regulated tyrosine kinase substrate HGS HIV-1 target according to Group 2, siRNA protein
P60953 cell division cycle 42 (GTP binding protein 25 kDa) CDC42 HIV-1 target according to Group 1 and predictions
P62988 ribosomal protein S27a RPS27A HIV-1 target according to Group 1, predications and experts, known drug target
O43597 sprouty homolog 2 (Drosophila) SPRY2 None