Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors

BMC Genomics

Table 1 Before-after relations between branch points and rate-limiting enzymes.

	RL_after_BP	RL_before_BP	Substrate_of_RL	Product_of_RL
Human	49	45	78	67
Liver
Central	3	4	6	7
Anabolic	18	19	40	35
Catabolic	14	12	26	24
Energetic	1	2	3	2

RL_after_BP column records the number of rate-limiting enzymes which occur directly after certain branch points. RL_before_BP column records the number of rate-limiting enzymes which occur directly before certain branch points. Substrate_of_RL column records the number of branch points, which are substrates of certain rate-limiting enzymes. Product_of_RL column records the number of branch points, which are products of certain rate-limiting enzymes. The human liver row is the statistic for the entire human liver dataset, and the other four rows are the statistics for the enzymes and branch points from central, anabolic, catabolic and energetic pathways.

ISSN: 1471-2164