Figure 1

Propensity for cleavage sites to occur in secondary structures. A. Propensities for different secondary structure elements (coils, C_p; helices, H_p; β-strands, E_p) were measured for 24-mer subsequences with or without caspase cleavage sites (labelled "cleavage sites" and "non-cleavage sites" respectively). B. Distribution of "cleavage sites" and "non-cleavage sites" subsequences to C_p bins. Each C_p bin (0.10, 0.20...1.00) was allocated a proportion of sequences with C_p scores falling within the bin range (0-0.10, 0.11-0.19...0.91-1.00).