Figure 8

Expression profile of the Red and Act antibiotics biosynthesis gene cluster. The expression change of these genes, as a consequence of the metabolic switch, leads to the production of pigment antibiotics that characterizes the stationary growth phase of Streptomyces. Their upregulation is shifted by many hours, relative to the phosphate starvation, indicating a systematic delay in their regulatory mechanism. The gene expression levels are closely correlated to the increase in antibiotics levels measured in the medium. A list of the genes and their expression data is included in the supplementary table. Upper plot: Red cluster; lower plot: Act cluster.