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Figure 1 | BMC Genomics

Figure 1

From: Computational prediction and experimental validation of evolutionarily conserved microRNA target genes in bilaterian animals

Figure 1

Computational extraction of conserved miRNA/target gene pairs among bilaterian animals. Evolutionarily conserved miRNAs were extracted from the five model species (H. sapiens, M. musculus, G. gallus, D. melanogaster, and C. elegans). For each miRNA, potential target genes were predicted using the following criteria: optimal free-energy threshold and complete matching of nucleotide sequences between the seed sequence of miRNA/mRNA duplexes (step 1), binding pattern of the 3'-UTR of miRNA/mRNA duplexes (step 2), and orthologous gene information (step 3).

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BMC Genomics

ISSN: 1471-2164

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