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Table 3 Evolutionarily conserved genes regulated by miRNAs

From: Computational prediction and experimental validation of evolutionarily conserved microRNA target genes in bilaterian animals

Target gene

     

ID

Name

Function

let-7

miR-1

miR-124

miR-125/lin4

miR-34

Candidates targeted by multiple miRNAs

ENSG00000095203

EPB41L4B

Band 4.1-like protein 4B

 

+**

+

  

Candidates targeted by single miRNAs

ENSG00000187772

LIN28B

Lin-28 homolog B

+

    

ENSG00000198799

LRIG2

Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor

+

    

ENSG00000086544

ITPKC

Inositol-trisphosphate 3-kinase C

+

    

ENSG00000196233

LCOR

Ligand-dependent corepressor

+

    

ENSG00000139263

LRIG3

Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor

+

    

ENSG00000134698

EIF2C4

Eukaryotic translation initiation factor 2C 4

+

    

ENSG00000170456

DENND5B

MGC24039 protein

+

    

ENSG00000136231

IGF2BP3

Insulin-like growth factor 2 mRNA-binding protein 3

+

    

ENSG00000158710

TAGLN2

Transgelin-2

 

+*

   

ENSG00000143549

TPM3

Tropomyosin alpha-3 chain

 

+*

   

ENSG00000117519

CNN3

Calponin-3

 

+

   

ENSG00000071073

MGAT4A

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

 

+

   

ENSG00000161813

LARP4

La-related protein 4

 

+

   

ENSG00000147416

ATP6V1B2

Vacuolar ATP synthase subunit B, brain isoform

 

+

   

ENSG00000135862

LAMC1

Laminin subunit gamma-1 precursor

  

+*

  

ENSG00000125695

STRADA

STE20-related adapter protein

  

+

  

ENSG00000131459

GFPT2

Glucosamine--fructose-6-phosphate aminotransferase

  

+

  

ENSG00000111145

ELK3

ETS domain-containing protein Elk-3

  

+

  

ENSG00000151726

ACSL1

Long-chain-fatty-acid--CoA ligase 1

  

+

  

ENSG00000164144

ARFIP1

Arfaptin-1

  

+**

  

ENSG00000080819

CPOX

Coproporphyrinogen III oxidase, mitochondrial precursor

  

+

  

ENSG00000138279

ANXA7

Annexin A7

  

+

  

ENSG00000150093

ITGB1

Integrin beta-1 precursor

  

+**

  

ENSG00000093167

LRRFIP2

Leucine-rich repeat flightless-interacting protein 2

  

+

  

ENSG00000116141

MARK1

Serine/threonine-protein kinase MARK1

   

+

 

ENSG00000166797

FAM96A

Protein FAM96A

   

+

 

ENSG00000131914

LIN28

Lin-28 homolog A

   

+*

 

ENSG00000113282

CLINT1

EPN4_HUMAN Isoform 2 of Q14677 - Homo sapiens

    

+

ENSG00000137872

SEMA6D

Semaphorin-6D precursor

    

+

  1. List of conserved targets regulated by conserved miRNAs. Transcript of Band 4.1-like protein 4B is only regulated by two miRNAs (miR-1 and miR-124). "*" and "**" indicates experimentally verified miRNA-mRNA and possible miRNA-mRNA candidates revealed by microarray data, respectively.
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BMC Genomics

ISSN: 1471-2164

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