Figure 4

Histogram indicating the major biological processes in untreated Wrn^Δhel/Δhelmouse embryonic fibroblasts significantly changed compared to untreated wild type cells. (A) The biological processes with a Benjamini value less than 0.05 are presented for untreated Wrn^Δhel/Δhelmouse embryonic fibroblasts versus untreated wild type cells (baseline level) as the -log10 of the Benjamini value. The black and gray bars represent the up and down regulated cellular processes, respectively. (B) Venn diagrams showing the number of down regulated biological processes overlapping between untreated Wrn^Δhel/Δheland H₂O₂-treated wild type mouse embryonic fibroblasts.