Intra and inter-run variation in UHRR samples: Pearson-correlations. Pairwise UHRR Pearson-correlation heatmaps highlight the batch differences, particularly between run 2 and run 4. Red cells correspond to ~97% correlation and white to 100% correlation. Batches and sample numbers are consistent with the colouring and labelling in Figure 1. All data were detection filtered, as described in methods. A = raw data; B = normalised; C = quantile normalised, plus mean-centring; D = quantile normalised, plus ComBat.