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Figure 5 | BMC Genomics

Figure 5

From: Correcting for intra-experiment variation in Illumina BeadChip data is necessary to generate robust gene-expression profiles

Figure 5

Intra and Inter-run comparisons of clinical duplicates. Mean Pearson-correlations between replicate pairs of tumour samples (A and B) on different chips and runs. Colours denote the four different data types; raw, quantile normalised (QN), quantile normalised then mean centred (QN+MC), and quantile normalised then ComBat corrected (QN+CB). Expressions were generally highly correlated except in the chips straddling runs 4 and 5. ComBat is able to correct for a significant amount of this difference. Error bars represent the standard error.

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