Table 1 Transcription factor binding site enrichment in clusters
Cluster | TFBS | Promoter range [kb]a | Gene hits | Z-scoreb | Fisher scoreb |
|---|---|---|---|---|---|
1 (local, 936 DEG) | RELA | -5/5 | 244 | 20.45 | 7.97E-05 |
| Â | NF-kappaB | -5/5 | 287 | 12.30 | 2.94E-04 |
| Â | REL | -2/0 | 206 | 19.26 | 4.04E-04 |
| Â | ELF5 | -5/5 | 530 | 16.69 | 5.71E-04 |
| Â | STAT1 | -5/5 | 119 | 12.44 | 5.84E-04 |
| Â | SRF | -5/5 | 48 | 12.10 | 8.09E-04 |
| Â | SPIB | -2/2 | 502 | 11.23 | 2.09E-03 |
| Â | Fos | -5/2 | 393 | 10.51 | 2.90E-03 |
2 (systemic, 703 DEG) | NFIL3 | -2/2 | 100 | 12.72 | 4.53E-03 |
| Â | TP53 | -5/2 | 3 | 13.36 | 3.87E-02 |
| Â | HLF | -2/2 | 127 | 13.06 | 4.23E-02 |
3 (systemic, 367 DEG) | FOXD1 | -2/2 | 128 | 13.09 | 5.19E-07 |
| Â | Foxa2 | -5/2 | 158 | 12.46 | 2.75E-06 |
| Â | Fos | -2/2 | 146 | 13.04 | 2.77E-05 |
| Â | Pdx1 | -2/0 | 156 | 23.12 | 3.63E-05 |
| Â | FOXI1 | -2/0 | 93 | 14.90 | 9.69E-05 |
| Â | SRY | -5/2 | 192 | 18.15 | 1.55E-04 |
| Â | PBX1 | -2/0 | 29 | 11.26 | 1.97E-04 |
| Â | REL | -2/0 | 92 | 10.49 | 2.57E-04 |
| Â | Foxd3 | -5/2 | 150 | 12.46 | 8.87E-04 |
| Â | Sox5 | -5/2 | 192 | 12.63 | 9.38E-04 |
| Â | Nkx2-5 | -2/2 | 188 | 23.31 | 9.98E-04 |
| Â | Lhx3 | -2/0 | 81 | 14.12 | 1.10E-03 |
| Â | Prrx2 | -2/2 | 174 | 20.48 | 1.91E-03 |
| Â | NFIL3 | -5/2 | 78 | 10.24 | 1.37E-04 |
4 (systemic, 41 DEG) | PBX1 | -2/2 | 9 | 10.26 | 1.89E-03 |
| Â | STAT1 | -5/2 | 9 | 12.03 | 7.36E-03 |
5 (systemic, 36 DEG) | HNF4A | -2/0 | 7 | 10.21 | 4.44E-02 |
| Â | NR2F1 | -2/0 | 4 | 12.14 | 9.58E-02 |
6 (local, 252 DEG) | Hand1-Tcfe2a | -2/2 | 129 | 10.40 | 2.31E-07 |