Figure 3

Comparison of phenotypic and expression profiles. A) Enriched GO-terms in the 169 genes deleted in the CTBT sensitive mutant strains are indicated in the left panels. Sensitivity levels to 2 and 4 μg/ml CTBT are colour coded as indicated. GO, sensitivity and expression data were hierarchical clustered. Genes belonging to two clusters which are highly expressed and the corresponding mutants highly sensitivity are enlarged and indicate involvement of superoxide dismutases and oxidative stress specific transcription factors. B) Comparison of CTBT sensitive strains to hydrogen peroxide, menadion, mefloquine and ibuprophen sensitive strains. Fitness values (log2 transformed) from [22] were clustered with CTBT sensitivity values (2 very sensitive, 1 sensitive, 0 insensitive). To visualize all genes included in these graphs in TreeView, the raw data are available as supplementary files. C) A Venn diagram shows the overlap between CTBT and datasets from Tucker and Fields [22].