Figure 6

Structure, calculated theoretical data and growth inhibition caused by CTBT and related compounds. Log P: partition coefficient in octanol-water system; μ: dipole moment of isolated molecule; HOMO: energy of the Highest Occupied Molecular Orbital; LUMO: energy of the Lowest Unoccupied Molecular Orbital. DGIZ: diameter of growth inhibition in zone inhibition assay on solid medium caused by CTBT [5 μg added to paper disk (diameter of 6 mm)]. CTBT: 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine; 1: tetrazolo [5,1-c]benzo[1,2,4]triazine; 2: 7-methyltetrazolo [5,1-c]benzo[1,2,4]triazine; 3: [1,2,4]triazolo [3,4, c]benzo[1,2,4]triazine; 4: 7-chloro[1,2,4]triazolo [3,4, c]benzo[1,2,4]triazine; 5: 1-bromo[1,2,4]triazolo [3,4, c]benzo[1,2,4]triazine.