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Figure 7 | BMC Genomics

Figure 7

From: Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine)

Figure 7

Scheme of proposed CTBT induced superoxide generation in mitochondria. Nde, external NADH dehydrogenase; Ndi, internal NADH dehydrogenase; Sdh, succinate dehydrogenase complex; Q, ubiquinone; bc1, cytochrome bc1 complex; c, cytochrome c; aa3, cytochrome c oxidase. In this model CTBT is reduced to CTBT.- radical by accepting an electron from the NADH dehydrogenases or the cytochrome bc1 complex.

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