Unified translation repression mechanism for microRNAs and upstream AUGs

BMC Genomics

Table 4 uAUGs from members of the KLF family predicted to interact with conserved miRNAs

KLF Gene^§	uAUG^†	miRNAs predicted to interact^‡
KLF6 (NM_001300)	uugcAUGaaac	hsa-miR-93 (3')
KLF7 (NM_003709)	cuggAUGccuc	hsa-miR-450b-3p (3'), hsa-miR-487a (3')
	cuggAUGucug	hsa-miR-450b-3p (3'), hsa-miR-487a (3')
KLF8 (NM_007250)	cucuAUGauuc	hsa-miR-376a (5'), hsa-miR-376b (5'),
		hsa-miR-376c (5')
	cuuuAUGuuca	None
	gaggAUGggug	hsa-miR-331-3p (3'), hsa-miR-363 (3'),
		hsa-miR-802 (3'), hsa-miR-99b (5')
	uuggAUGcuug	hsa-miR-450b-3p (3')
	cgcuAUGucag	hsa-miR-31 (3')
	cagaAUGgggc	hsa-miR-448 (3'), hsa-miR-583 (3')
		hsa-miR-136 (5')
	gaguAUGagcc	hsa-miR-767-3p (5')
	cggcAUGaguu	hsa-miR-574-3p (5')
KLF10 (NM_001032282, isoform a)	gauuAUGcaau	hsa-let-7d (3'), hsa-miR-153 (5')
	agcaAUGgcuc	hsa-miR-160 (5')
	caucAUGcauu	None
	aagaAUGuuuu	None
	uuuaAUGgaaa	None
KLF12 (NM_007249)	aucaAUGugac	hsa-miR-199a-3p (3')
		hsa-miR-23a (5')
		hsa-miR-23b (5')
	acaaAUGgaug	hsa-miR-136 (5')
	auggAUGaaug	hsa-miR-450b-3p (3')
		hsa-miR-487b (3')
		hsa-miR-802 (3')
	augaAUGaaua	None

^§ KLF13 and KLF9 are presented along with miRNA expression data in Table 3 and 5, respectively.
^† uAUGs are shown in caps.
^‡ Numbers in parentheses indicate the miRNA end predicted to interact. miRNAs in italics indicate matches with one GU wobble.

ISSN: 1471-2164