Depletion of the non-coding regulatory 6S RNA in E. coli causes a surprising reduction in the expression of the translation machinery

Table 2 Selected genes considered as meaningful¹, which show reduced expression levels (≥ 1.5-fold change) during exponential phase.

Synonym	Gene	Average mRNA level MM139/WT	Annotation
b0995	torR	0.66	response regulator in two-component regulatory system
b2808	gcvA	0.64	transcriptional dual regulator
b2980	glcC	0.63	DNA-binding transcriptional dual regulator, glycolate-binding
b1439	ydcR	0.63	fused predicted DNA-binding transcriptional regulator
b3319	rplD	0.63	50S ribosomal protein L4
b1526	yneJ	0.62	predicted transcriptional regulator
b3604	lldR	0.62	transcriptional repressor
b1320	ycjW	0.61	predicted transcriptional regulator
b1328	ycjZ	0.60	predicted transcriptional regulator
b3604	lldR	0.57	transcriptional repressor
b1014	putA	0.54	fused DNA-binding transcriptional repressor
b1334	fnr	0.53	global transcriptional dual regulator, anaerobic growth
b1649	ydhM	0.52	predicted transcriptional regulator
b2531	iscR	0.50	transcriptional dual regulator
b1916	sdiA	0.40	transcriptional dual regulator
b1422	ydcI	0.31	predicted transcriptional regulator
b2537	hcaR	0.29	transcriptional activator of 3-phenylpropionic acid catabolism

¹Meaningful genes were selected by the following criteria: known or predicted function related to the ssrS transcription unit, serving common or related functions, regulatory- and stress-related functions.

ISSN: 1471-2164