Figure 1
From: Myosin individualized: single nucleotide polymorphisms in energy transduction
Several myosin peptides or domains identified with energy transduction of ATP hydrolysis free energy to the mechanical work of moving actin. Structured (Myopathy and Cloop, AA363-377 and 404-417) and unstructured (Loops 2 and 3, AA626-651 and 568-580) surface loops are actin binding peptides (black). The 7-stranded β-sheet (green, AA116-127, 170-180, 248-257, 265-271, 458-468, and 671-678) mediates ATP hydrolysis and actin binding affinity modulation. The Switch 2 helix (blue, AA469-509) transmits translational movement in the active site to the converter domain (red, AA716-772) where it is converted to the torque needed to rotate the lever-arm (blue, AA773-813). The SH2/SH1 hinge (silver, AA688-715) undergoes a large conformation change with lever-arm rotation. The function of SH3 (yellow, AA30-80) in energy transduction is not yet understood. Not depicted are actin-binding-peptides at two sites in the upper half of the molecule.