Figure 3

The SH2/SH1 hinge (silver, AA688-715), converter (red, AA716-772), and lever-arm (blue, AA773-813). SNP residue annotation color coding corresponds to: cardiac myosin II (red), skeletal myosin II (blue), non-muscle myosin II (brown), and unconventional myosin (tan). Thirteen SNP substitution sites at M688, L694, H695, G701, R707, R710, V720, K723, P735, K743, L785, Q787, and A801 are depicted in gray or yellow with space filling models of the unsubstituted side chains. The yellow residues are also implicated in disease. R710 is adjacent to the reactive thiol residue (SH1 at C709) on the SH2/SH1 hinge. L785, Q787, and A801 are on the lever-arm and within the ELC binding region. The converter domain receives impulses from the Switch 2 helix that it converts into the torque needed rotate the lever-arm while the SH2/SH1 hinge changes conformation.