Figure 5

The SH3 domain (yellow, AA30-80) and 4 SNP substitution sites at P31, G57, V60, and A68 are depicted in gray with space filling models of the unsubstituted side chains. SNP residue annotation color coding corresponds to: cardiac myosin II (red), non-muscle myosin II (brown), and unconventional myosin (tan). The function of SH3 is unknown but it is implicated in transmission of influence from ELC to the active site and in supporting the binding of the ELC N-terminus to actin. Several SNP substituted residues adjacent to the 7-stranded β-sheet (Figure 2) are also adjacent to SH3 including I88, E89, H98, and E108.