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Table 2 Seed sequences enriched in high scoring siRNAs

From: Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis

Seed

Size

Normalized Enrichment Score

FWER p-val

Hexamers

   

TAATAA

70

2.691

0

ACTTGA

14

2.674

0

CCTTAA

16

2.642

0

AATTAA

44

2.567

0

ACTGGA

10

2.510

0

TAGGAA

13

2.505

0

TAAAGA

20

2.482

0.002

GAATAA

21

2.474

0.002

AAGTTA

20

2.426

0.004

TCACAA

12

2.413

0.005

AAATGA

21

2.405

0.005

AGATCA

35

2.378

0.006

TTATAA

22

2.335

0.009

AATATT

15

2.314

0.015

AGATCT

17

2.304

0.015

TGAATA

16

2.255

0.026

CTGGAA

8

2.198

0.047

Heptamers

   

CAATTAA

18

2.911

0.000

GAGATCA

18

2.387

0.001

GAAAGAA

10

2.241

0.015

TTAATAA

17

2.227

0.015

GTATTTA

16

2.211

0.016

ATAGGAA

6

2.187

0.021

ACCTTAA

8

2.185

0.021

TAATTAA

8

2.179

0.024

TTAATTA

10

2.151

0.037

ACAATTA

10

2.148

0.039

AAGATCA

13

2.140

0.041

CTAATAA

20

2.139

0.041

CTAATTA

7

2.136

0.043

  1. Table shows seed sequences designated enriched in high scoring siRNAs by GSEA. The number the seeds in the set, the enrichment score and the multiple testing corrected P value are shown.
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BMC Genomics

ISSN: 1471-2164

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