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Figure 3 | BMC Genomics

Figure 3

From: Comparative transcriptomic analysis of follicle-enclosed oocyte maturational and developmental competence acquisition in two non-mammalian vertebrates

Figure 3

Cyp17a1 amino acid sequence alignments among vertebrates. Amino acid sequence alignments between human CYP17A1 (ENSG00000148795, H. sapiens), mouse Cyp17a1 (NP_031835.3, M. musculus), chicken CYP17A1 (ENSGALG00000008121 peptide ENSGALP00000032532, G. gallus), clawed toad Cyp17a1 (AAG42003, X. laevis), zebrafish Cyp17a1 (AAI62669.1, D. rerio) and rainbow trout Cyp17a1 (NP_001118219.1, O. mykiss). Multiple amino acid sequence alignments were constructed using ClustalW software. The conserved domains previously identified are indicated: domain I (heme-binding domain [22]); domain II (putative steroid-binding domain [23]); domain III (CYP17 specific domain [21]). The amino acids that have been evidenced as essential for human CYP17 activity are indicated with asterisks (serine 106, aspartic acid 487, serine 488 and phenylalanine 489) [24, 25].

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BMC Genomics

ISSN: 1471-2164

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